Research progress regarding endocannabinoid system involvement in pain modulation and electroacupuncture analgesia  

作　　者：Renjie Qin Yisong Wu Nuo Jin Xingzhi Xu Yuye Lan Xianghong Jing Man Li 

机构地区：[1]School of Basic Medicine,Tongji Medical College,Key Laboratory of Anesthesiology and Resuscitation of Ministry of Education,Huazhong University of Science and Technology,Wuhan,China [2]Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing,China

出　　处：《Acupuncture and Herbal Medicine》2025年第1期36-45,共10页针灸和草药(英文)

基　　金：supported by the Key Program of the National Natural Science Foundation of China(82130122);the National Natural Science Foundation of China(81973949).

摘　　要：Pain is a subjective and unpleasant sensation that significantly impacts the daily lives of individuals.Chronic pain represents one of the most challenging public health issues,and ensuring effective pain management is a fundamental right of individuals and a sacred duty of healthcare providers.Cannabis,one of the earliest recognized medicinal plants,contains cannabinoids,which are non-opioid substances that modulate nociceptive responses.Electroacupuncture(EA),characterized by its low-risk and well-tolerated nature,is pivotal in pain management.The endocannabinoid system consists of endocannabinoids,cannabinoid receptors,and enzymes involved in endocannabinoid synthesis,degradation,and transport.Recently,the role of the endocannabinoid system in pain development and EA analgesia has attracted considerable research attention.Studies have highlighted the role of the endocannabinoid system in various types of pain,including inflammatory pain,neuropathic pain,and cancer-related pain,as well as in EA analgesia.This study aims to review the mechanisms of endocannabinoid system involvement in pain modulation and EA analgesia to provide insights to inform clinical approaches to pain management.

关 键 词：ELECTROACUPUNCTURE Endocannabinoid receptors Inflammatory pain Neuropathic pain 

分 类 号：R245[医药卫生—针灸推拿学]