血栓前状态分子及血清CTRP1水平对PCI术后患者预后的预测价值  

Value of prothrombotic state molecules and the serum level of complement C1q tumor necrosis factor-related protein 1 in predicting the prognosis of patients after percutaneous coronary intervention

作　　者：文博 WEN Bo(Department of Critical Heart Condition,Yellow River Sanmenxia Hospital,Sanmenxia 472000,China)

机构地区：[1]黄河三门峡医院心脏重症医学科,河南三门峡472000

出　　处：《精准医学杂志》2025年第2期158-161,共4页Journal of Precision Medicine

摘　　要：目的分析血栓前状态分子、血清补体C1q肿瘤坏死因子相关蛋白1(CTRP1)水平对经皮冠状动脉介入治疗(PCI)术后患者预后的预测价值。方法选取2018年1月—2020年2月在本院行PCI术患者86例,根据术后1年内是否发生重大不良心血管事件分为预后良好组(71例)与预后不良组(15例)。比较两组患者入院时血清CTRP1水平及血浆中D-二聚体(D-D)、血栓前体蛋白(TpP)、纤维蛋白原(Fbg)、血管性血友病因子(vWF)水平。绘制受试者工作特征(ROC)曲线并计算曲线下面积(AUC),评估上述指标对患者PCI术后预后的预测效能。结果预后良好组患者入院时血浆D-D、TpP、Fbg及vWF水平均显著低于预后不良组(t=2.094~5.664,P<0.05),血清CTRP1水平显著高于预后不良组(t=2.331,P<0.05)。ROC曲线显示,上述所有指标联合评估患者预后的灵敏度为93.33%,特异度为78.87%,诊断效能最佳(AUC=0.935)。结论血栓前状态分子及血清CTRP1水平联合预测PCI术后患者预后的准确性较高,临床可通过监测及调控上述指标以改善冠心病患者长期预后。Objective To investigate the value of prethrombotic state molecules and the serum level of complement C1q tumor necrosis factor-related protein 1(CTRP1)in predicting the prognosis of patients after percutaneous coronary intervention(PCI).Methods A total of 86 patients who underwent PCI in our hospital from January 2018 to February 2020 were enrolled,and according to the presence or absence of major adverse cardiovascular events within 1 year after surgery,they were divided into good prognosis group with 71 patients and poor prognosis group with 15 patients.The two groups were compared in terms of the serum level of CTRP1 and the plasma levels of D-dimer(D-D),thrombus precursor protein(TpP),fibrinogen(Fbg),and von Willebrand factor(VWF)on admission.The receiver operating characteristic(ROC)curve was plotted and the area under the ROC curve(AUC)was calculated to assess the performance of the above indicators in predicting the prognosis of patients after PCI.[WTHX]Results Compared with the poor prognosis group,the good prognosis group had significantly lower plasma levels of D-D,TpP,Fbg,and vWF(t=2.094-5.664,P<0.05)and a significantly higher serum level of CTRP1 on admission(t=2.331,P<0.05).The ROC curve analysis showed that the combination of these indicators had the best performance in assessing the prognosis of patients,with an AUC of 0.935,a sensitivity of 93.33%,and a specificity of 78.87%.Conclusion Prethrombotic state molecules and serum CTRP1 level have a high accuracy in predicting the prognosis of patients after PCI,and these indicators can be monitored in clinical practice to improve the long-term prognosis of patients with coronary heart disease.

关 键 词：冠心病 经皮冠状动脉介入治疗 血栓形成倾向 补体C1Q 预后 

分 类 号：R541.4[医药卫生—心血管疾病] R814.47[医药卫生—内科学]