视频脑电图联合C反应蛋白和降钙素原对伴惊厥发作中枢神经系统感染性疾病的诊断价值研究  

Diagnostic value of video-electroencephalography combined with CRP and PCT in infectious diseases of the central nervous system with convulsions

作　　者：张海燕 吴莉莉[1] 尹远远[2] 张颖[3] Zhang Haiyan;Wu Lili;Yin Yuanyuan;Zhang Ying(Department of Electrophysiology,Bengbu First People's Hospital,Bengbu 233000,China;Department of Pediatrics,Bengbu First People's Hospital,Bengbu 233000,China;Department of Traditional Chinese Medicine,Bengbu First People's Hospital,Bengbu 233000,China)

机构地区：[1]蚌埠市第一人民医院电生理科,蚌埠233000 [2]蚌埠市第一人民医院儿科,蚌埠233000 [3]蚌埠市第一人民医院中医科,蚌埠233000

出　　处：《中国医学装备》2025年第4期43-47,共5页China Medical Equipment

基　　金：安徽省卫生健康科研项目(AHWS2022b112)。

摘　　要：目的:分析视频脑电图(VEEG)联合C反应蛋白(CRP)、降钙素原(PCT)对伴惊厥发作中枢神经系统感染性疾病的诊断价值。方法:选取2022年5月至2024年5月于蚌埠市第一人民医院诊治的100例伴惊厥发作疑似中枢神经系统感染患儿,均行VEEG检查和实验室检测,通过检测脑脊液判断是否为中枢神经系统感染而将其分为感染组(36例)和非感染组(64例),比较两组VEEG检测异常情况(包括正常、正常范围、界限性和异常),以及与CRP、PCT水平,分析VEEG联合CRP、PCT诊断结果与脑脊液检查结果的一致性,采用受试者工作特征(ROC)曲线,分析VEEG联合CRP、PCT的诊断效能。结果:感染组36例患儿中VEEG检测正常范围2例(占5.56%),界线性11例(占30.56%),异常23例(占63.89%);非感染组64例患儿中正常54例(占84.38%),正常范围6例(占9.38%),界线性3例(占4.68%),异常1例(占1.56%)。感染组异常情况明显高于非感染组,差异有统计学意义(Z=8.81,P<0.05);感染组CRP和PCT水平亦明显高于非感染组,差异有统计学意义(t=6.859、5.410,P<0.05);VEEG联合CRP、PCT诊断与脑脊液检查结果一致性较高(Kappa=0.867);ROC分析显示,VEEG联合CRP、PCT诊断伴惊厥发作中枢神经系统感染的ROC曲线下面积(AUC)、灵敏度及特异度分别为0.963、86.11%和98.44%,AUC、灵敏度、特异度均高于VEEG单独诊断。结论:伴惊厥发作中枢神经系统感染患儿VEEG异常情况,CRP和PCT水平与非中枢神经系统感染伴惊厥发作患者相比差异显著,临床应用VEEG联合CRP、PCT诊断具有较高的诊断效能。Objective:To analyze the diagnostic value of video-electroencephalography(VEEG)combined with C-reactive protein(CRP)and procalcitonin(PCT)in infectious diseases of the central nervous system with convulsions.Methods:This study included 100 pediatric patients with convulsions who were suspected as central nervous system infection at Bengbu First People's Hospital from May 2022 to May 2024.VEEG and laboratory tests were performed on them.These patients were divided into the infection group(36 cases)and the non-infection group(64 cases)according to whether they were judged as central nervous system infection by using testing cerebrospinal fluid.The abnormal situation of VEEG test,CRP and PCT levels of two groups were compared,and the consistency between the diagnostic result of VEEG combined with CRP and PCT,and the tested result of cerebrospinal fluid was further analyzed.The receiver operating characteristic(ROC)curve was adopted to analyze the diagnostic efficiency of VEEG combined with CRP and PCT.Results:In 36 pediatric patients of infection group,2 cases(5.56%)were within normal range of VEEG examination,and 11 cases(30.56%)were at cutoff value,and 23 cases(63.89%)were abnormal.In 64 pediatric patients of non-infection group,54 cases(84.38%)were normal,and 6 cases(9.38%)were within normal range,and 3 cases(4.68%)were at cutoff value,and 1cases(1.56%)were abnormal.The abnormal results of the infection group were significantly higher than those of the non-infection group(Z=8.81,P<0.05).The CRP and PCT levels of infection group were significantly higher than those of non-infection group(t=6.859,5.410,P<0.05).There was higher consistency between the diagnosis of VEEG combined with CRP and PCT,and the tested result of cerebrospinal fluid(Kappa=0.867).The ROC analysis showed that the AUC value,sensitivity and specificity of VEEG combined with CRP and PCT in diagnosing the central nervous system infection with convulsions were respectively 0.963,86.11%and 98.44%,which were higher than those of the single VEEG diagnos

关 键 词：视频脑电图(VEEG) C反应蛋白(CRP) 降钙素原(PCT) 惊厥 中枢神经系统感染 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]