超声引导下微波消融联合无水乙醇消融治疗甲状腺囊实性结节的疗效及安全性分析  

Analysis of the curative efficacy and safety of ultrasound-guided MWA combined with PEI in treating thyroid cystic solid nodule

作　　者：周凡 张少红 徐长松[1] 穆正青 陆军 Zhou Fan;Zhang Shaohong;Xu Changsong;Mu Zhengqing;Lu Jun(Department of Medical Ultrasound,The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University,Huai'an 223300,China;Department of Geriatrics,The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University,Huai'an 223300,China)

机构地区：[1]南京医科大学附属淮安第一医院超声科,淮安223300 [2]南京医科大学附属淮安第一医院老年医学科,淮安223300

出　　处：《中国医学装备》2025年第4期84-89,共6页China Medical Equipment

基　　金：国家自然科学基金(82305149)。

摘　　要：目的:探讨微波消融(MWA)联合无水乙醇消融(PEI)治疗甲状腺囊实性结节的疗效及安全性。方法:选取2021年1月至2022年12月南京医科大学附属淮安第一医院收治的62例甲状腺囊实性结节患者,根据治疗方案的不同将其分为微波组(28例,单纯MWA)和联合组(34例,MWA联合PEI)。对比分析两组治疗后甲状腺结节体积缩小率、甲状腺功能指标、临床症状及体征评分,以及围术期并发症发生率。结果:治疗后联合组甲状腺结节体积平均缩小率为(88.97±6.36)%,高于微波组的(88.15±5.69)%,两组比较差异有统计学意义(t=2.465,P<0.05)。两组治疗前后甲状腺功能指标比较,差异均无统计学意义(P>0.05)。两组治疗后临床症状及体征评分均低于治疗前,同期临床症状及体征评分比较差异无统计学意义(P>0.05)。联合组围术期并发症发生率为17.65%,低于微波组的42.86%,两组比较差异有统计学意义(x^(2)=4.736,P<0.05)。结论:MWA联合PEI治疗甲状腺囊实性结节疗效优于单纯微波消融,且安全性较高。Objective:To explore the curative efficacy and safety of microwave ablation(MWA)combined with percutaneous ethanol injection(PEI)in treating thyroid cystic solid nodule.Methods:A total of 62 patients with thyroid cystic solid nodule,who admitted to The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University from January 2021 to December 2022,were selected,and they were divided into microwave group(n=28,only single MWA)and combination group(n=34,MWA combined with PEI)according to different treatment plans.The reduction rate of the volume of thyroid nodules,indicators of thyroid function,clinical symptom and the score of physical signs,as well as the incidence of perioperative complications,were compared between two groups after treatment.Results:After treatment,the reduction rate of the volume of thyroid nodule was(88.97±6.36)%in the combination group,which was higher than that(88.15±5.69)%in the microwave group,and the differences in those indicators between the two groups were statistically significant(t=2.465,P<0.05).The differences of the indicators of thyroid function before and after treatment between two groups were not significant(P>0.05).The clinical symptoms and the scores of physical signs of both groups after treatment were lower than that before treatment(P>0.05).The incidence of perioperative complications in the combination group was 17.65%,which was lower than 42.68%in the microwave group(P<0.05),and the difference of that between the two groups was significant(x^(2)=4.736,P<0.05).Conclusion:The curative efficacy of the combination of MWA and PEI is better than MWA alone,which has better safety.

关 键 词：甲状腺结节 微波消融(MWA) 无水乙醇消融(PEI) 超声引导 安全性 

分 类 号：R445.1[医药卫生—影像医学与核医学]