基于数据挖掘探析当代名老中医治疗不孕症用药规律  

Analysis on Medication Law of Contemporary Renowned Famous Veteran Teran Doctors of TCM in the Treatment of Infertility Based on Data Mining

作　　者：郭方兰 高兴莲 刘大泽 代国龙 万凯铭 周啟萍 王华[2] GUO Fanglan;GAO Xinglian;LIU Daze;DAI Guolong;WAN Kaiming;ZHOU Qiping;WANG Hua(Zhaotong Hospital of Traditional Chinese Medicine/Zhaotong Hospital Affiliated to Yunnan University of Chinese Medicine,Zhaotong 657000,China;Kunming Maternal and Child Health Hospital,Kunming 650031,China)

机构地区：[1]昭通市中医医院/云南中医药大学附属昭通医院,云南昭通657000 [2]昆明市妇幼保健院,云南昆明650031

出　　处：《云南中医药大学学报》2025年第2期63-68,共6页Journal of Yunnan University of Chinese Medicine

基　　金：云南省应用基础研究中医联合专项(202101AH070062);云南中医药大学校院联合基金项目(XYLH202226);云南省中医特色专科(2022年);云南省中医临床重点学科(2023年)。

摘　　要：目的基于数据挖掘方法探析当代名老中医治疗不孕症用药规律。方法搜集中国知网(CNKI)、万方数据(Wanfang Data)、维普中文期刊服务平台(VIP)及相关图书中不孕症医案,建立数据库,应用中医传承平台统计及方剂分析功能进行疾病谱、中医证型、频次分析、药物属性、关联规则及K-means聚类分析。结果纳入研究医案366个、处方421首,涉及中药327味,累计用药5704次。排卵障碍、输卵管阻塞、卵巢储备功能下降、子宫内膜异位症、免疫性不孕为高频疾病。肾虚血瘀、脾肾亏虚、肝郁肾虚、痰湿阻滞等8个证型为辨证高频证型。功效类别以补虚、活血化瘀类药最为常用,频次≥100的中药16味,药性以温最多,药味以甘为主,归经以肝、脾、肾三经为主。关联规则得出13组核心药物。聚类分析得出4个类方。结论当代名老中医治疗不孕症以补肾为主,重视女子以血为本的理论,治以补肾活血、疏肝理气、健脾利湿为主,遣方用药以毓麟珠、养精种玉汤、开郁种玉汤为基础方化裁。Objective To explore the medication rule of contemporary famous veteran teran doctors of TCM in treating infertility based on data mining.Methods Retrieve medical cases of TCM on the treatment of infertility from CNKI,Wan fang Data,VIP and related books,then set up a database,apply the statistical and prescription analysis function of TCM inheritance support system(TCMISS)to perform disease spectrum,TCM syndrome types,frequency analysis,properties of TCM,association rules and K-means clustering analysis.Results 366 medical cases of TCM were included in the study,421 prescriptions were obtained,327 drugs of traditional Chinese medicine were involved,and the drugs were used for a total of 5704 times.Ovulation disorders,tubal obstruction,decreased ovarian reserve function,endometriosis,and immune infertility are the high frequency diseases.The eight evidence types of kidney deficiency and blood stasis,spleen-kidney deficiency,stagnation of liver Qi and kidney deficiency,stagnation and blockade of phlegm-damp are identified as high-frequency evidence types.The efficacy category of Chinese medicine is most commonly used to replenish deficiency,invigorate blood circulation and remove blood stasis,with a frequency of≥100 for 16 Chinese herbal medicines,the medicinal property was mainly warm,the medicinal taste was mainly sweet,and the meridians were mainly liver,kidney and spleen.Association rules yielded 13 core drug groups.Cluster analysis yielded 4 class parties.Conclusion Contemporary famous veteran teran doctors of TCM treat infertility by tonifying the kidney,emphasizing the theory that blood is the basis for a woman’s life,and using medicines to tonify the kidney and activate the blood,soothing liver-Qi stagnation,strengthen the spleen and promote dampness.The Chinese herbal prescriptions were based on Yulin Zhu,Yangjing Zhongyu decoction,Kaiyu Zhongyu decoction,respectively.

关 键 词：不孕症 当代名老中医 数据挖掘 用药规律 

分 类 号：R271.14[医药卫生—中医妇科学]