50例迪庆藏族肺高压患者的临床特征分析  

Analysis of clinical characteristics of 50 Zang nationality patients with pulmonary hypertension in Diqing

作　　者：何姗姗 叶孟奇 付斐 赏飞燕 廖秋艳 郭涛 李郭三 HE Shanshan;YE Mengqi;FU Fei;SHANG Feiyan;LIAO Qiuyan;GUO Tao;LI Guosan(Arrhythmia 2nd ward,Yunnan Fuwai Hospital of Cardiovascular Diseases,Kunming Yunnan 650101,China;Department of vascular surgery,First People s Hospital of Yunnan Province,Kunming Yunnan 650032,China)

机构地区：[1]云南省阜外心血管病医院心律失常二病区,云南昆明650101 [2]云南省第一人民医院血管外科,云南昆明650032

出　　处：《云南医药》2025年第2期1-5,共5页Medicine and Pharmacy of Yunnan

基　　金：云南省科技厅科技计划项目(202103AC100004)。

摘　　要：目的探讨迪庆(高原地区)藏族肺动脉高压患者临床特征、生化指标、超声心动图等指标,找出快速简便的方法实现对高原PH的早期诊断。方法回顾性分析2019年9月-2024年7月在云南省阜外心血管病医院住院的高原地区藏族患者,通过1∶1倾向评分匹配后,纳入50例高原藏族肺高压患者与50例高原藏族非肺高压患者,收集患者一般资料、生命体征、实验室资料、超声心动图指标等,2组基线资料及临床指标进行比较,多因素logsitic回归分析找出PH的影响因素,并进一步通过ROC曲线分析相关指标对PH的预测价值。结果迪庆藏族肺高压患者的COPD史、OSA史、收缩压、ALB、TC、载脂蛋白a、RDW、NEUT、NT-proBNP、LA、LV、EF与正常肺动脉压患者相比差异有统计学意义;LANEUT曲线下面积0.695,敏感度0.52,特异性:0.80,LA曲线下面积0.726,敏感度0.58,特异性0.78。LANEUT与LA联合预测时曲线下面积0.803,敏感度0.66,特异性0.88。结论外周血中性粒细胞计数和左心房内径对迪庆藏族PH有预测价值,两者联合价值更高,似可用于迪庆藏族PH患者的早期识别和优化管理。Objective To explore the clinical characteristics,biochemical indicators,echocardiography and other indicators of Zang nationality pulmonary hypertension patients in Diqing(plateau area),and find out a quick and simple method to achieve the early diagnosis of pulmonary hypertension(PH)at high altitude.Methods Retrospective analysis was performed on Zang nationality patients in plateau area who were hospitalized in Fuwai Cardiovascular Disease Hospital of Yunnan Province from September 2019 to July 2024.After 1∶1 propensity score matching,50 Zang nationality patients with pulmonary hypertension and 50 Zang nationality patients without pulmonary hypertension were included.General data,vital signs,laboratory data and echocardiographic indicators of the patients were collected.The baseline data and clinical indicators of the two groups were compared,and the influencing factors of PH were identified by multi-factor logsitic regression analysis.Furthermore,the predictive value of relevant indexes to PH was analyzed by ROC curve.Results The COPD history,OSA history,systolic blood pressure,albumin(ALB),total cholesterol(TC),apolipoprotein a,red blood cell volume distribution width(RDW),neutrophill absolute value(NEUT),NT-proBNP,left atrial anterior and posterior diameter(LA),left ventricular anterior and posterior diameter(LV),left ventricular ejection fraction(EF)of Zang nationality patients with pulmonary hypertension in Diqing were significantly different from those of normal pulmonary hypertension.Area under LANEUT curve was 0.695,sensitivity was 0.52,specificity was 0.80,area under LA curve was 0.726,sensitivity was 0.58,specificity was 0.78.When LANEUT and LA combined predicted,the area under the curve was 0.803,the sensitivity was 0.66,and the specificity was 0.88.Conclusions Both peripheral blood neutrophil count and left atrial diameter have predictive value for Diqing Zang nationality PH patients,and the combined value is higher,which may be used for early identification and optimal management of Zang nationa

关 键 词：中性粒细胞绝对值 左心房前后径 肺动脉高压 藏族 

分 类 号：R544.1[医药卫生—心血管疾病]