血浆NLRP3水平与急性心肌梗死患者心脏重构的相关性  

The correlation between plasma NLRP3 levels and cardiac remodeling in patients with acute myocardial infarction

作　　者：梁慧颖 石媛 马航 李娜[1] 李琳[1] LIANG Huiying;SHI Yuan;MA Hang;LI Na;LI Lin(Department of Cardiology,First Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China;Department of Cardiology,Yunnan Fuwai Hospital of Cardiovascular Diseases,Kunming Yunnan 650102,China;Department of Cardiology,Northeast Regional Central Hospital of Yunnan,Zhaotong Yunnan 657000,China)

机构地区：[1]昆明医科大学第一附属医院心内科,云南昆明650032 [2]云南省阜外心血管病医院心内科,云南昆明650102 [3]云南省滇东北区域中心医院心血管内科,云南昭通657000

出　　处：《云南医药》2025年第2期9-12,共4页Medicine and Pharmacy of Yunnan

基　　金：国家自然科学基金(81560072);云南省科学技术厅-昆明医科大学应用基础研究联合专项资金[2019FE001(-056)];云南省心脑血管疾病临床医学中心建设项目(ZX2019-03-01)。

摘　　要：目的探讨血浆NLRP3水平与AMI患者心脏重构的相关性。方法选择2020年12月-2021年8月在昆明医科大学第一附属医院心脏内科住院的60例AMI患者,检测血浆中NLRP3、IL-1β、IL-6、CRP及sST2水平,收集患者临床资料及超声心动图指标,分析AMI患者血浆NLRP3水平与心脏重构指标的相关性。结果血浆NLRP3高水平组LVESVI、LVEDD、LVMI较低水平组有增加趋势,LVEF、LVFS较低水平组有降低趋势,但差异没有统计学意义(P>0.05)。AMI患者血浆NLRP3水平与IL-1β、IL-6、CRP和sST2的水平呈正相关(P<0.05),但与心脏重构指标无显著相关性(P>0.05)。结论AMI患者血浆NLRP3水平与AMI后心脏重构无明显相关性。Objective To explore the correlation between plasma NLRP3 level and cardiac remodeling in patients with acute myocardial infarction(AMI).Methods 60 AMI patients admitted to the Department of Cardiology,the First Affiliated Hospital of Kunming Medical University from December 2020 to August 2021 were selected.The plasma level of NLRP3,IL-1β,IL-6,CRP and sST2 were measured,and the clinical data and indexes of echocardiography of patients were collected.The correlation between plasma NLRP3 levels and cardiac remodeling indexes in AMI patients was analyzed.Results LVESVI,LVEDD and LVMI of plasma NLRP3 in the high level group had an increasing trend compared to the low level group,while the LVEF and LVFS had a decreasing trend compared to the low level group,but the differences were not statistically significant(P>0.05).The plasma levels of NLRP3 in AMI patients were positively correlated with the plasma IL-1β,IL-6,CRP and sST2 levels(P<0.05),but there was no significant correlation with cardiac remodeling index(P>0.05).Conclusions There was no significant correlation between plasma NLRP3 level and cardiac remodeling in AMI patients.

关 键 词：NLRP3炎症小体 急性心肌梗死 心脏重构 

分 类 号：R542.22[医药卫生—心血管疾病]