硫辛酸联合中药透药在糖尿病周围神经病变患者的应用  

Application of lipoic acid combined with Chinese medicine transudate in diabetic peripheral neuropathy patients

作　　者：赵佳丽[1] 李海英[1] 岳全[2] 李琼芬[1] 施蓉蓉[1] 吴海菁 ZHAO Jiali;LI Haiying;YUE Quan;LI Qiongfen;SHI Rongrong;WU Haijing(Department of Endocrinology,,Yuxi Hospital of Traditional Chinese Medicine,Yuxi Yunnan 653100,China;Department of Nursing,Yuxi Hospital of Traditional Chinese Medicine,Yuxi Yunnan 653100,China)

机构地区：[1]玉溪市中医医院内分泌科,云南玉溪653100 [2]玉溪市中医医院护理部,云南玉溪653100

出　　处：《云南医药》2025年第2期40-43,共4页Medicine and Pharmacy of Yunnan

基　　金：云南中医药大学护理专项基金项目(YZHY202330)。

摘　　要：目的分析硫辛酸联合中药透药在DPN患者中的应用效果。方法选取2024年1月-2024年8月云南省某三级中医医院内分泌科就诊的DPN患者100例,随机分为对照组和观察组各50例,2组均实施常规治疗、护理,静脉滴注硫辛酸等措施,观察组使用中药在双侧足三里、阴陵泉、三阴交等腧穴进行透药,总疗程10d。比较2组患者的临床疗效及干预前、后CSIT评分,腓总神经、胫神经、腓肠神经SNCV、MNCV的改变。结果干预后,观察组总有效率优于对照组,差异有统计学意义(P<0.05);2组CSIT评分均较干预前下降,差异有统计学意义(P<0.05);2组CSIT评分干预后组间比较,差异有统计学意义(P<0.05);腓总神经、胫神经和腓肠神经SNCV、MNCV较干预前提高,差异有统计学意义(P<0.05)。结论硫辛酸联合中药透药可提高DPN患者的治疗效果及神经传导速度,改善CSIT评分。Objective To analyze the application effect of lipoic acid combined with Chinese medicine transudate in diabetic peripheral neuropathy(DPN)patients.Methods A total of 100 DPN patients treated in the Department of Endocrinology of a tertiary hospital TCM hospital in Yunnan Province from January to August 2024 were selected and randomly divided into control group and the observation group with 50 patients each in group,and both groups received conventional treatment,nursing care and intravenous infusion of lipoic acid and other measures.The observation group used traditional Chinese medicines to permeate medicines at the acupoints of the bilateral ZuSanli,Yinlingquan and Sanyinjiao for a total duration of 10 d.The clinical efficacy,CSIT score,SNCV and MNCV changes of common peroneal nerve,tibial nerve and sural nerve before and after the intervention peroneal were compared between the two groups.Results After intervention,the total effective rate of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05);CSIT scores of both groups decreased compared with that before intervention,and the difference was statistically significant(P<0.05);CSIT scores of the two groups were statistically significant when compared between the two groups after intervention(P<0.05);SNCV and MNCV of total peroneal nerve,tibial nerve,and sural nerve were higher than those before intervention(P<0.05);and the total peroneal nerve,tibial nerve and peroneal nerve SNCV and MNCV increased compared with that before intervention,and the difference was statistically significant(P<0.05).Conclusions Lipoic acid combined with Chinese medicine transudate can improve the therapeutic effect and nerve conduction velocity of DPN patients,and improve the CSIT score.

关 键 词：硫辛酸 糖尿病周围神经病变 消渴痹症 中药 定向透药疗法 

分 类 号：R587.2[医药卫生—内分泌] R747.9[医药卫生—内科学]