炎症反应在肺癌伴新型冠状病毒感染患者中的研究进展  

Research progress of inflammation in patients with lung cancer and COVID-19 infection

作　　者：何繁漪(综述) 陆霓虹 杜映荣(审校) HE Fanyi;LU Nihong;DU Yingrong(Public Laboratory and Department of Emerging Infectious Disease Research,Kunming Third People's Hospital/Yunnan Clinical Medical Center for Infectious Disease,Kunming Yunnan 650041,China;Department of Respiratory and Critical Care Medicine,Kunming Third People's Hospital/Yunnan Clinical Medical Center for Infectious Disease,Kunming Yunnan 650041,China;Department of Infectious Disease,Kunming Third People's Hospital/Yunnan Clinical Medical Center for Infectious Disease,Kunming Yunnan 650041,China)

机构地区：[1]昆明市第三人民医院/云南省传染性疾病临床医学中心公共实验室暨新发传染病研究部,云南昆明650041 [2]昆明市第三人民医院/云南省传染性疾病临床医学中心呼吸与危重症医学科,云南昆明650041 [3]昆明市第三人民医院/云南省传染性疾病临床医学中心感染科,云南昆明650041

出　　处：《云南医药》2025年第2期74-78,共5页Medicine and Pharmacy of Yunnan

基　　金：新冠病毒感染后综合征发病机制及防治体系研究示范项目(202303AC100026)。

摘　　要：COVID-19全球大流行对肺癌患者产生了前所未有的持续影响,因为他们比正常人群更容易受到病毒感染。事实上,这两种疾病的发病、进展和预后会相互影响,而炎症是它们之间的重要联系。肺癌患者原有的慢性炎症环境可能会增加感染COVID-19的风险,加重继发性损伤。同时,COVID-19引起的急性炎症可能诱导肿瘤进展或导致免疫激活。目前,多学科诊疗是临床医师面临的主要挑战,本文从急慢性肺部炎症的角度,总结分析这些特殊患者肺部的病理生理变化,探讨两种疾病可能相互促进的分子免疫机制,为肺癌患者新型冠状病毒感染的治疗和预防提供建议。The global pandemic of coronavirus disease-2019(COVID-19)has had an unprecedented continuous impact on lung cancer patients,because they are more vulnerable to the virus infection than the normal people.In fact,the morbidity,progression,and prognosis of these two diseases affect each other,and inflammation is an important link between them.The pre-existing chronic inflammatory environment of lung cancer patients may increase the risk of COVID-19 infection and exacerbate secondary damage.Meanwhile,acute inflammation caused by COVID-19 may induce tumor progression or lead to immune activation.At present,multidisciplinary diagnosis and treatment is the main challenge faced by clinicians.From the perspective of acute and chronic pulmonary inflammation,this article summarizes and analyzes the pathophysiological changes in the lungs of these special patients,discusses the molecular immune mechanism that the two diseases may promote each other,so as to provide suggestions for the treatment and prevention of novel coronavirus infection in lung cancer patients.

关 键 词：新型冠状病毒 肺癌 炎症反应 免疫反应 

分 类 号：R511[医药卫生—内科学]