舒肝解郁胶囊对慢性心力衰竭伴焦虑抑郁患者心功能和心理状态的影响  

Effects of Shugan Jieyu capsules on cardiac function and state of mind of chronic heart failure patients with anxiety and depression

作　　者：王斌 逄帅 吕水利 常快乐 WANG Bin;PANG Shuai;LÜShuili;CHANG Kuaile(Department of Cardiology,the First Affiliated Hospital of Air Force Medical University,Xi′an 710032,China;Department of Pharmacy,No.987 Hospital of Joint Logistic Support Force of PLA,Baoji,Shaanxi 721004,China;Department of Cardiology and Nephrology,No.987 Hospital of Joint Logistic Support Force of PLA,Baoji,Shaanxi 721004,China)

机构地区：[1]空军军医大学第一附属医院心脏内科,西安710032 [2]联勤保障部队第九八七医院药剂科,陕西宝鸡721004 [3]联勤保障部队第九八七医院心肾内科,陕西宝鸡721004

出　　处：《军事医学》2025年第2期110-113,共4页Military Medical Sciences

基　　金：陕西省科学技术厅国际科技合作计划项目(2023-GHYB-12)。

摘　　要：目的 观察舒肝解郁胶囊对慢性心力衰竭(CHF)伴焦虑抑郁患者心功能和心理状态的影响。方法 将94例CHF伴焦虑抑郁患者随机分为舒肝解郁胶囊治疗组和心理干预对照组,每组各47例。采用t检验和χ~2检验比较两组患者在治疗前后的焦虑自评量表(SDS)评分、抑郁自评量表(SAS)评分、左室射血分数(LVEF)、N端B型钠尿肽前体(NTpro-BNP)、6分钟步行实验测试(6MWT)、血红蛋白(Hb)、白细胞介素-6(IL-6)、白蛋白(ALB)及高敏C反应蛋白(hs-CRP)的变化。结果 治疗8周后,治疗组SDS评分、SAS评分、NT-proBNP、hs-CRP和IL-6均显著低于治疗前及对照组;LVEF、6WMT、Hb和ALB均显著高于治疗前及对照组。结论 舒肝解郁胶囊能有效缓解CHF患者的焦虑抑郁情绪,改善患者心功能和营养状态,同时减轻机体炎症反应。Objective To study the effects of Shugan Jieyu capsules on the cardiac function and state of mind of chronic heart failure(CHF)patients with anxiety and depression.Methods Ninety-four CHF patients with anxiety and depression were randomly divided into the Shugan Jieyu capsule treatment group and mental therapy control group.Self-rating depression Scale(SDS),self-rating anxiety scale(SAS),left ventricular ejection fraction(LVEF),N-terminal pro-B-type natriuretic peptide(NT-proBNP),the 6-minute walking test(6MWT),hemoglobin(Hb),interleukin-6(IL-6),albumin(ALB)and high-sensitivity c-reactive protein(hs-CRP)were compared between the two groups before and after treatment using t-tests and chi-square tests in order to find out about the efficacy of Shugan Jieyu capsules in CHF patients with anxiety and depression.Results After 8 weeks of treatment,SDS,SAS,NT-proBNP,hs-CRP and IL-6 were all significantly lower,especially in the treatment group,while LVEF,6MWT,Hb and ALB were significantly higher or longer,particularly in the treatment group.Conclusion Shugan Jieyu capsules can effectively alleviate anxiety and depression in CHF patients,improve the cardiac function and nutritional status,and mitigate inflammation.

关 键 词：舒肝解郁胶囊 慢性心力衰竭 焦虑 抑郁 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]