ICU成人患者中心静脉导管相关皮肤损伤风险预测模型的构建及验证  

Development and validation of a risk prediction model of central venous catheter-associated skin injury in adult patients in the intensive care unit

作　　者：黄慧 纪超娜[2] 陈丽婵 陈燕宏 陈惜遂[3] HUANG Hui;JI Chaona;CHEN Lichan;CHEN Yanhong;CHEN Xisui(The First Affiliated Hospital of Shantou University Medical College,Shantou,515041,China;不详)

机构地区：[1]汕头大学医学院第一附属医院重症医学科一区,汕头市515041 [2]汕头大学医学院第一附属医院胆胰微创外科介入科,汕头市515041 [3]汕头大学医学院第一附属医院护理部,汕头市515041 [4]汕头大学医学院护理学系

出　　处：《中华急危重症护理杂志》2025年第4期389-395,共7页Chinese Journal of Emergency and Critical Care Nursing

基　　金：中华护理杂志社2023年静脉治疗护理专项科研项目(ZHHLZZS-202324)。

摘　　要：目的构建并验证ICU成人患者中心静脉导管(central venous catheter,CVC)相关皮肤损伤(catheter-associated skin injury,CASI)风险预测模型。方法采取便利抽样法,选取2023年1月—10月广东省某三级甲等综合医院符合纳入和排除标准的ICU患者为调查对象,通过单因素分析和二元Logistic回归分析确定危险因素并构建预测模型。采用受试者操作特征曲线下面积、校准曲线评价模型的区分度和校准度,采用临床决策曲线评价模型的临床有效性。结果研究纳入434例ICU患者,发生CVC-CASI 68例,发生率为15.7%,共发生74例次CVC-CASI,其中非感染性渗出54例次,占73.0%。模型变量包括留置时间、置管部位、俯卧位通气、皮肤水肿、血清白蛋白、凝血酶原时间、活化部分凝血活酶时间及穿刺次数。模型验证效果显示,受试者操作特征曲线下面积为0.838(95%CI为0.784~0.893),灵敏度为77.9%,特异度为81.1%,最大约登指数为0.59。结论ICU患者CVC-CASI的发生率较高,该研究构建的预测模型具有较好的预测效能,能够为临床医护人员早期识别高危人群和及时进行干预提供理论依据。Objective This study developed and validated a risk prediction model of central venous catheter-associated skin injury(CVC-CASI)in patients in the intensive care unit.Methods Using convenience sampling,clinical data were obtained for ICU patients who were admitted to a tertiary grade A hospital in Guangdong Province between January 2023 and October 2023.Independent risk factors for CVC-CASI were identified by univariate and binary logistic regression analyses.And a risk prediction model was constructed.The discrimination and calibration of the model was evaluated by the area under the receiver-operating characteristic(ROC)curve and calibration curve,and the clinical effectiveness was assessed by the clinical decision curve.Results 68 of the 434 patients who were included in the study developed CVC-CASI,giving an incidence rate of 15.7%.74 cases of CVC-CASI occurred,with non-infectious exudation accounting for 54 cases(73.0%).Model variables included catheter dwelling time,catheterization site,prone ventilation,skin edema,serum albumin,prothrombin time,activated partial thromboplastin time,and puncture frequency.The model validation results showed that the area under the ROC curve was 0.838(95%confidence interval 0.784-0.893)with a sensitivity of 77.9%and a specificity of 81.1%.The Youden index was 0.59.Conclusion The incidence of CVC-CASI in ICU patients is relatively high.Our prediction model has good prediction efficiency and can provide theoretical basis for early identification of high-risk populations and timely intervention for clinical medical staff.

关 键 词：ICU 中心静脉导管 导管相关皮肤损伤 预测模型 列线图 护理 

分 类 号：R472[医药卫生—护理学]