西南绣球甾体类化学成分研究  

Steroid Chemical Constituents of Hydrangea davidii

作　　者：戚万仙 李港 姜北 肖朝江 Qi Wangxian;Li Gang;Jiang Bei;Xiao Chaojiang(Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan,Dali,Yunnan 671000,China;Institute of Materia Medica,Dali University,Dali,Yunnan 671000,China;College of Pharmacy,Dali University,Dali,Yunnan 671000,China)

机构地区：[1]云南省滇西抗病原植物资源筛选研究重点实验室,云南大理671000 [2]大理大学药物研究所,云南大理671000 [3]大理大学药学院,云南大理671000

出　　处：《大理大学学报》2025年第4期6-10,共5页Journal of Dali University

基　　金：国家自然科学基金项目(82460689);云南省高层次科技人才及创新团队选拔专项-中青年学术和技术带头人后备人才项目(202405AC350025);云南省滇西抗病原植物资源筛选研究重点实验室研究生项目(APR2023Y03);云南省专家工作站项目(202405AF140029)。

摘　　要：目的:了解西南绣球茎和根的化学成分。方法:对西南绣球茎和根的95%乙醇提取物乙酸乙酯萃取部位运用多种柱色谱技术进行化学成分分离纯化,依据理化性质和核磁波谱数据对化合物进行结构鉴定。结果:从西南绣球茎和根中分离得到8个甾体化合物,分别鉴定为:β-谷甾醇(1)、(3β,7α)-7-甲氧基豆甾-5-烯-3-醇(2)、(3β,7β)-7-甲氧基豆甾-5-烯-3-醇(3)、豆甾-3β,6α-二醇(4)、豆甾-4-烯-6β-醇-3-酮(5)、豆甾-3,6-二酮(6)、7-氧谷甾醇(7)、胡萝卜苷(8)。结论:化合物1~8为首次从西南绣球中分离得到,其中化合物2~8首次从绣球属植物中分离得到。Objective:To investigate the chemical constituents of the stems and roots of Hydrangea davidii.Methods:The chemical components of 95%ethyl acetate extract from the stems and roots of H.davidii were separated and purified by various column chromatography techniques.The structures of the compounds were identified based on physicochemical properties and NMR data.Results:Eight steroids were isolated from the stems and roots of H.davidii,which were identified asβ-sitosterol(1),(3β,7α)-7-methoxystigmast-5-en-3-ol(2),(3β,7β)-7-methoxystigmast-5-en-3-ol(3),stigmastane-3β,6α-diol(4),stigmast-4-en-6β-ol-3-one(5),stigmastane-3,6-dione(6),7-oxositosterol(7),and daucostero(l 8).Conclusion:Compounds 1−8 were isolated from H.davidii for the first time,and compounds 2−8 were isolated from Hydrangea genus for the first time.

关 键 词：西南绣球 化学成分 甾体 提取分离 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]