不同数据标准化方法结合不同权重赋值在汉桃叶微丸制备工艺优化中的比较研究  

Comparative Study on Different Data Standardization Methods Combined with Different Weight Assignments in the Preparation Process Optimization of Hantaoye Micropills

作　　者：鄢海燕 木永祥 邹纯才 Yan Haiyan;Mu Yongxiang;Zou Chuncai(School of Pharmacy,Wannan Medical College,Wuhu,Anhui 241002,China)

机构地区：[1]皖南医学院药学院,安徽芜湖241002

出　　处：《大理大学学报》2025年第4期11-20,共10页Journal of Dali University

基　　金：安徽高校自然科学研究项目(KJ2016SD60);皖南医学院药剂学一流本科课程(2019ylkc017);安徽省省级质量工程项目(2019kfkc084)。

摘　　要：目的:探讨不同数据标准化方法结合不同权重赋值对汉桃叶微丸制备工艺的影响。方法:以极小化法、极大化法、极差化法、标准差标准化法、均值化变换法、对数标准化法等6种数据标准化方法结合层次分析法(AHP)、G1、熵权法(EWM)、CRITIC、AHP-EWM、AHP-CRITIC、G1-EWM、G1-CRITIC、参照文献、权重平均等10种权重赋予方法对汉桃叶微丸制备工艺单因素试验及Box-Behnken响应面试验结果进行分析。结果:不同数据标准化方法结合不同权重赋值对单因素试验综合评价指标无明显影响,对Box-Behnken响应面法优化结果显示,各组模型显著性P<0.01,失拟项P<0.05的有:对数标准化法结合10种权重赋值,极差化法结合EWM、CRITIC、G1-EWM,标准差标准化法结合EWM。结论:汉桃叶微丸制备工艺单因素最佳水平的确定不受数据标准化方法结合权重赋值的影响,采用Box-Behnken响应面法时以极小化-G1-EWM法最佳。Objective:To investigate the effect of different data standardization methods combined with different weight assignments on the preparation process of Hantaoye micropills.Methods:The results of the single factor test and the Box-Behnken response surface test on the preparation process of Hantaoye micropills were analyzed by six data standardization methods,including minimalization,maximalization,polarization,standard deviation standardization,homogenization transformation,and logarithmic standardization in combination with 10 weight assignment methods,including the analytic hierarchy process(AHP),G1,entropy weight method(EWM),CRITIC,AHP-EWM,AHP-CRITIC,G1-EWM,G1-CRITIC,literature and weight averaging.Results:Different data standardization methods combined with different weight assignments had no significant effect on the comprehensive evaluation indexes of the single factor test.The optimization results of Box-Behnken response surface method showed that the model significance of each group was P<0.01,and the missing fitting item with P<0.05 was as follows:the logarithmic standardization method combined with the 10 weight assignments,the polarization method combined with the EWM,CRITIC and G1-EWM,and the standard deviation standardization method combined with the EWM.Conclusion:The determination of the single-factor optimal level for the preparation process of Hantaoye micropills is not affected by the data standardization method combined with weight assignments and the minimization-G1-EWM is the best method when Box-Behnken response surface method is used.

关 键 词：数据标准化 权重赋值 Box-Behnken响应面法 工艺优化 

分 类 号：R927.11[医药卫生—药学]