超级微波消解-ICP-MS检测血浆中17种微量元素  

Detection of 17 trace elements in plasma by super microwave digestion-ICP-MS

作　　者：刘研 陈小云 赵燕[1] 陈婧司 秦立强[1] 王坤 Liu Yan;ChenXiaoyun;Zhao Yan;Chen Jinsi;Qin Liqiang;Wang Kun(School of Public Health,Medical College of Soochow University,Suzhou 215123,China;Yancheng Center for Disease Control and Prevention,Yancheng 224000,China)

机构地区：[1]苏州大学医学院公共卫生学院,苏州215123 [2]盐城市疾控中心,盐城224000

出　　处：《分析仪器》2025年第2期60-63,共4页Analytical Instrumentation

摘　　要：目的:采用超级微波消解-电感耦合等离子体质谱仪(inductively coupled plasma mass spectrometry,ICP-MS)建立血浆中17种微量元素含量的测定分析方法。方法:血浆样品经超级微波消解仪消解后,采用ICP-MS检测微量元素银(Ag)、铝(Al)、钡(Ba)、镉(Cd)、钴(Co)、铬(Cr)、铜(Cu)、铁(Fe)、锰(Mn)、钼(Mo)、镍(Ni)、铅(Pb)、锑(Sb)、硒(Se)、钍(Th)、钒(V)、锌(Zn)。结果:该方法在各元素的线性相关系数均优于0.999,元素的低、中、高浓度加标回收率为81.20%~119.80%,各元素的日内精密度为0.94%~4.71%。结论:该方法准确、快速、方便,适用于血浆中元素的测定。Plasma samples were digested by using a supermicrowave digestion system,and trace elements(silver(Ag),aluminum(Al),barium(Ba),cadmium(Cd),cobalt(Co),chromium(Cr),copper(Cu),iron(Fe),manganese(Mn),molybdenum(Mo),nickel(Ni),lead(Pb),antimony(Sb),selenium(Se),thorium(Th),vanadium(V),and zinc(Zn))were detected by ICP-MS.The method exhibited that the linear correlation coefficients for all elements exceeded 0.999,while low,medium,and high concentration spike recoveries ranged from 81.20%to 119.80%.The intra-day precision for each element ranged from 0.94%to 4.71%.The method is accurate,rapid,and convenient,and suitable for the determination of elements in plasma.

关 键 词：超级微波消解 电感耦合等离子体质谱法 血浆样品 微量元素 

分 类 号：R446.1[医药卫生—诊断学]