2010—2023年浙江省杭州市手足口病流行特征及病原学分析  

Epidemiological and etiological characteristics of hand-foot-mouth disease in Hangzhou,Zhejiang Province,2010‒2023

作　　者：冯爽 任晓宾[1] 王哲 贺兆锴 陶焱炀 考庆君[1] 孙昼[1] FENG Shuang;REN Xiaobin;WANG Zhe;HE Zhaokai;TAO Yanyang;KAO Qingjun;SUN Zhou(Hangzhou Center for Disease Control and Prevention(Hangzhou Health Supervision Institute),Hangzhou,Zhejiang 310021,China)

机构地区：[1]杭州市疾病预防控制中心(杭州市卫生监督所),浙江杭州310021

出　　处：《上海预防医学》2025年第2期129-134,共6页Shanghai Journal of Preventive Medicine

基　　金：杭州市卫生科技计划一般(A)类项目(A20230046)。

摘　　要：【目的】了解杭州市手足口病(HFMD)流行特征及变化趋势,为防治措施制定及防控效果评价提供科学依据。【方法】杭州市HFMD病例资料来自中国疾病预防控制信息系统传染病报告信息管理系统,应用描述流行病学分析2010—2023年杭州市HFMD病例的三间分布特征及病原学监测结果,应用Joinpoint回归模型分析发病率变化趋势,应用圆形分布法计算发病高峰。【结果】2010—2023年杭州市手足口病年均报告发病率为138.85/10万,重症比例为0.04%,死亡率为0.01/10万,病死率为5.30/10万。总发病率、分性别发病率均呈上升趋势。男性年均报告发病率(158.72/10万)高于女性(117.61/10万)。报告发病率呈明显的季节性特征,夏季为流行高峰。监测样本分析结果提示杭州市HFMD呈现多种病原体并存的流行特征,优势病原体早期以EV⁃A71型和CV⁃A16为主,2018年后以CV⁃A6型为主。EV⁃A71型在重症病例中构成比(77.19%)高于普通病例(15.37%),其在普通病例、重症及死亡病例中的占比均呈下降趋势。【结论】杭州市HFMD发病率仍然较高,需继续加强重点人群的防控工作。近些年杭州市以CV⁃A6型为主要流行病原体,需进一步加强病原学监测和分析工作。[Objective]To analyze the epidemiological characteristics and trends of hand-foot-mouth disease(HFMD)in Hangzhou,so as to provide an evidence for developing effective prevention and control measures and evaluating the control effects.[Methods]The incidence data of HFMD in Hangzhou were collected from the Infectious Disease Reporting Information Management System of China Information System for Disease Control and Prevention.Descriptive epidemiology was applied to analyze the temporal,spatial and demographic distribution characteristics and etiology monitoring results of HFMD cases in Hangzhou from 2010 to 2023.Joinpoint regression model was used to analyze the trends of incidence rate of HFMD.Furthermore,circular distribution method was utilized to calculate the incidence peak of HFMD.[Results]From 2010 to 2023,the average annual reported incidence rate of HFMD in Hangzhou was 138.85/100000,the proportion of severe cases was 0.04%,the mortality rate was 0.01/100000,and the case fatality rate was 5.30/100000.Both the total incidence rate and the incidence rate by sex showed an increasing trend.The annual reported incidence rate in males(158.72/100000)was higher than that in females(117.61/100000).The reported incidence rate showed a significant seasonal characteristic,with summer being the peak of epidemic.The results of surveillance samples suggested that the prevalence of HFMD in Hangzhou is characterized by the co-existence of multiple pathogens,with EVA71 and CV-A16 being the dominant pathogens in the previous years and CV-A6 being the dominant pathogen since 2018.The proportion of EV-A71 in severe cases(77.19%)was higher than that in ordinary cases(15.37%),in addition,its proportion in ordinary cases,severe cases,and fatal cases all showed a decreasing trend.[Conclusion]The incidence rate of HFMD in Hangzhou is still high,so it’s still necessary to continue to strengthen the prevention and control measures for key populations.In recent years,CV-A6 has been the main prevalent pathogen in Hangzhou.Further eff

关 键 词：手足口病 流行病学特征 病原学 儿童 Joinpoint回归 

分 类 号：R183.4[医药卫生—流行病学]