自主跑轮运动对抑郁症模型小鼠中枢多巴胺及受体的影响  

Effect of voluntary wheel running on dopamine and its receptor in the central nervous system of depression model mice

作　　者：何利民 张静 HE Li-min;ZHANG Jing(Section of Physical Education,Lanzhou University,Lanzhou 730000,China;College of Physical Education and Health,Nanning Normal University,Nanning 530100,China)

机构地区：[1]兰州大学体育教研部,兰州730000 [2]南宁师范大学体育与健康学院,南宁530100

出　　处：《兰州大学学报(自然科学版)》2025年第2期238-245,共8页Journal of Lanzhou University(Natural Sciences)

基　　金：南宁师范大学博士科研启动基金项目(602021239350)。

摘　　要：探究自主跑轮运动(VWR)在改善小鼠焦虑、抑郁样行为中的作用.C57BL/6小鼠随机分为正常对照组(12只)和抑郁症建模组(40只),采用慢性社会挫败应激(CSDS)方法建立抑郁症模型.建模成功的小鼠随机分为抑郁症模型组(CSDS组)和抑郁症模型运动干预组(CSDS+VWR组),各12只.正常对照组和CSDS组安静饲养,CSDS+VWR组进行连续VWR,共3周.运动结束后采用旷场实验和高架十字迷宫实验检测小鼠焦虑样行为,采用强迫游泳和悬尾实验检测小鼠的抑郁样行为.行为测试结束后,取小鼠脑组织进行机制检测.研究发现,CSDS导致小鼠出现焦虑样及抑郁样行为与中枢系统多巴胺含量下降有关.VWR可能通过增强多巴胺水平,进而改善小鼠的抑郁症状.VWR改善小鼠抑郁可能是通过增强伏隔核脑区D2R受体水平来实现的.To investigated the effect of voluntary wheel running(VWR) on anxiety-like and depressionlike behaviors in mice.C57BL/6 mice were randomly divided into a normal control group(12 mice) and depression model group(40 mice).The depression model mice was established by chronic social defeat stress(CSDS).Mice that modeled successfully were randomly divided into depression model group(CSDS group) and depression model exercise intervention group(CSDS+VWR group),12 in each group.The normal control and CSDS groups were fed quietly,while the CSDS+VWR group given VWR,3weeks.After the VWR,anxiety-like behavior was detected by open field test and elevated plus maze test,and depression-like behavior detected by forced swimming test and tail suspension test.After the behavioral test,the brain tissues of the mice were taken for mechanism detection.Research found that anxiety-like and depression-like behaviors in mice induced by CSDS were related to the decrease of dopamine levers in central nervous system.VWR might improve mice depression by enhancing dopamine levels.VWR might improve mice depression by enhancing the protein expressions of D2R receptor in nucleus accumbens.

关 键 词：自主跑轮运动 慢性社会挫败应激 抑郁 多巴胺 伏隔核 

分 类 号：G804.2[文化科学—运动人体科学]