X射线技术在矿物药研究中的应用  

Application of X-ray Technology in Mineral Chinese Medicine Research

作　　者：钱喜龙 章芊芊 朱星宇 刘政 黄梓轩 赵劲[4] 刘圣金[1,2] QIAN Xilong;ZHANG Qianqian;ZHU Xingyu;LIU Zheng;HUANG Zixuan;ZHAO Jin;LIU Shengjin(State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture(Jangsu Kanion Pharmaceutical Co.,Ltd.,Nanjing University of Chinese Medicine),Nanjing 210023,China;School of Pharmacy,Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Nanjing University of Chinese Medicine,Nanjing 210023,China;Jiangsu College of Nursing,Huai'an 223001,China;Chemistry and Biomedicine Innovation Center(Chem BIC),School of Chemistry and Chemical Engineering Nanjing University,Nanjing 210023,China)

机构地区：[1]南京中医药大学中药制药过程控制与智能制造技术全国重点实验室,江苏南京210023 [2]南京中医药大学药学院/江苏省中药资源产业化过程协同创新中心,江苏南京210023 [3]江苏护理职业学院,江苏淮安223001 [4]南京大学化学和生物医药创新研究院/化学化工学院,江苏南京210023

出　　处：《中国现代中药》2025年第4期779-784,共6页Modern Chinese Medicine

基　　金：江苏省高等学校基础科学(自然科学)研究重大项目(24KJA360006);国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023083);教育部科技委2021年战略研究项目。

摘　　要：矿物药是中医药宝库中的重要组成部分,应用历史悠久。随着科学技术的发展及学科交叉融合,X射线技术已经逐渐应用到矿物药研究中,为矿物药的基原(矿种)鉴定、成分(物相)分析和质量控制提供了技术支撑。综述了X射线技术在矿物药研究中的应用进展,探讨其在该领域的应用潜力及面临的挑战。X射线衍射分析技术能够有效地对矿物药进行晶体结构分析和鉴定,用于矿物药的质量控制;X射线荧光光谱分析技术在元素分析方面显示出独特的优势,能够快速准确地测定矿物药中元素的含量;同时,X射线技术与机器学习算法的结合为复杂数据的解析和矿物药的分类提供了新的视角。X射线技术在矿物药研究中的应用前景广阔。Mineral Chinese medicine,as an integral component of the treasure trove of traditional Chinese medicine(TCM),has a long-standing history of application.With the advancement of science and technology,as well as the interdisciplinary integration of scientific research,X-ray technology has been increasingly applied to the study of mineral Chinese medicine.This application has provided technical support for the origin(type)identification of mineral Chinese medicine,component(phase)analysis,and quality control of mineral Chinese medicine.This paper introduced the progress in the application of X-ray technology in mineral Chinese medicine research,discusses its application potential and challenges within this field,and summarized the current application state of X-ray technology in mineral Chinese medicine research.X-ray diffraction(XRD)technology can effectively analyze and identify the crystal structure of mineral Chinese medicine and is used for quality control of mineral Chinese medicine.X-ray fluorescence(XRF)technology demonstrates its unique advantages in elemental analysis,rapidly and accurately determining the elemental content in mineral Chinese medicine.Furthermore,the integration of X-ray technology with machine learning algorithms offers a new perspective for the analysis of complex data and the classification of mineral Chinese medicine.The application prospects for X-ray technology in mineral Chinese medicine research are broad.

关 键 词：X射线衍射分析 X射线荧光光谱分析 矿物药 中药 质量控制 学科交叉 

分 类 号：R282[医药卫生—中药学]