抑郁症缰核的磁共振成像研究进展  

Advances in magnetic resonance imaging of the habenula in depression

作　　者：侯琳 卞冰阳 张惠茅[1] 张磊[1] HOU Lin;BIAN Bingyang;ZHANG Huimao;ZHANG Lei(Department of Radiology,the First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院放射科,长春130021

出　　处：《磁共振成像》2025年第3期104-108,137,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:82102143);吉林省科技发展计划项目(编号:YDZJ202402029CXJD);吉林省科技创新基地(平台)建设项目(编号:YDZJ202402080CXJD);吉林大学第一医院青年发展基金项目(编号:JDYY15202413)。

摘　　要：缰核(habenula,Hb)是一对位于脑深部的灰质小核团,作为联系边缘前脑与中脑之间重要的枢纽,在情绪调控中发挥关键作用,缰核的过度兴奋已被证实与抑郁症的发病密切相关。磁共振成像技术不断发展以及同人工智能的深度融合,不仅加深了人们对缰核参与抑郁症的发病机制的认识,也帮助完善了抑郁症的诊疗及预后手段。本文着重对抑郁症缰核的MRI、分割及影像学改变进行总结,并探讨了目前的研究面临的技术挑战,从而为抑郁症的早期诊断及个性化治疗策略提供新的思路。The habenula(Hb) is a pair of small grey nuclei located in the deep part of the brain,which plays a key role in emotion regulation as an important hub connecting the limbic forebrain and the midbrain,and overexcitability of this nucleus has been proved to be closely related to the onset of depression.The continuous development of MRI technology and its deep integration with artificial intelligence have not only deepened people's understanding of the involvement of the Hb in the pathogenesis of depression,but also helped to improve the diagnosis,treatment and prognosis of depression.In this paper,we provide a concise overview of the MRI,segmentation and imaging changes of the Hb in depression,discuss the challenges of current research,and provide new ideas for early diagnosis and personalized treatment strategies for depression.

关 键 词：缰核 抑郁症 磁共振成像 图像处理 深度学习 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.4[医药卫生—诊断学]