针刺治疗脑卒中后抑郁的多模态MRI研究进展  

Advances in multimodal MRI of acupuncture for post-stroke depression

作　　者：刘可妍 杨可钦 赵彬[2] 王格格 LIU Keyan;YANG Keqin;ZHAO Bin;WANG Gege(Graduate School of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Rehabilitation Centre,Heilongjiang University of Chinese Medicine Affiliated Second Hospital Rehabilitation Center,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学附属第二医院康复中心,哈尔滨150001

出　　处：《磁共振成像》2025年第3期109-115,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：黑龙江省卫生健康委科研课题项目(编号:20222020011074);黑龙江省博士后基金项目(编号:LBH-Z22290)。

摘　　要：脑卒中后抑郁(post stroke depression,PSD)是一种以情绪低落、兴趣缺失为主要表现的情绪障碍综合征,是脑卒中后常见的并发症。针刺治疗PSD疗效肯定,通过针刺治疗可以改善抑郁状态,但其机理尚需深入研究。多模态MRI对PSD异常脑区具有精准定位和观察即刻效应的优势,为针刺治疗PSD在脑机制研究和疗效评估方面提供了有效证据和可视化支持。本文将从静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)、弥散张量成像(diffusion tensor imaging,DTI)、基于体素的形态学测量(voxel-based morphometry,VBM)、磁共振波谱成像(magnetic resonance spectroscopy,MRS)等方面,对针刺治疗PSD脑结构、功能连接、脑内神经元活动、脑白质纤维束完整性及灰质结构等相关文献进行综述,分析PSD的相关脑内变化来探究针刺治疗机制,为PSD的针刺治疗提供新思路。Post-stroke depression(PSD) is a mood disorder syndrome characterized by emotional depression and loss of interest,which is a common complication after stroke.Acupuncture treatment for PSD has proven effective in improving depressive symptoms,but its mechanism requires further investigation.Multimodal MRI has the advantage of accurately locating and observing the immediate effects of abnormal brain regions in PSD,providing effective evidence and visual support for the study of the brain mechanism and efficacy evaluation of acupuncture treatment for PSD.This review will summarize the literature on acupuncture treatment for PSD from the perspectives of resting-state functional magnetic resonance imaging,diffusion tensor imaging,voxel-based morphometry,and magnetic resonance spectroscopy.By analyzing cerebral structural changes,functional connectivity,neuronal activity,white matter fiber tract integrity,and gray matter structure related to PSD,we aim to investigate the mechanisms underlying acupuncture therapy and provide new insights into acupuncture treatment for PSD.

关 键 词：针刺 脑卒中后抑郁 磁共振成像 静息态功能磁共振成像 弥散张量成像 基于体素的形态学测量 磁共振波谱成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743.3[医药卫生—诊断学] R749.2[医药卫生—临床医学]