定量磁化率成像技术在帕金森病中的研究进展  

Research progress of quantitative susceptibility mapping in Parkinson's disease

作　　者：石玥 董林菘 陈绍华 李洪义 杜禹辛 魏秀芳 SHI Yue;DONG Linsong;CHEN Shaohua;LI Hongyi;DU Yuxin;WEI Xiufang(Mudanjiang Medical University,Mudanjiang 157011,China;Department of Magnetic Resonance Imaging,Imaging Center,Hongqi Hospital Affiliated to Mudanjiang Medical University,Mudanjiang 157011,China)

机构地区：[1]牡丹江医科大学,牡丹江157011 [2]牡丹江医科大学附属红旗医院影像中心磁共振科,牡丹江157011

出　　处：《磁共振成像》2025年第3期122-126,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：黑龙江省重点研发计划项目(编号:SC2024ZX12C0036);黑龙江省省属高等学校基本科研业务费科研项目(编号:2023-KYYWFMY-0014)。

摘　　要：帕金森病(Parkinson's disease,PD)是一种迟发性神经退行性疾病,发病率逐年增长,脑内铁动态平衡失调被认为是PD重要病理学特征之一。近年来,神经影像学领域取得了显著的进展,为PD的临床诊断及病理机制的深入剖析开辟了全新视野。在这一背景下,定量磁化率成像(quantitative susceptibility mapping,QSM)技术作为一种先进的磁共振成像手段,利用磁共振成像中的相位信息,实现了对脑组织铁含量精确量化评估。本文就QSM技术成像原理及在PD诊断中的潜在价值与应用前景予以综述,为PD的诊断提供新思路。Parkinson's disease(PD) is a late-onset neurodegenerative disorder with an increasing incidence year by year.The dysregulation of iron homeostasis in the brain is regarded as one of the significant pathological features of PD.In recent years,remarkable progress has been made in the field of neuroimaging,which has opened up new vistas for the clinical diagnosis of PD and the in-depth exploration of its pathological mechanisms.Against this backdrop,quantitative susceptibility mapping(QSM) technology,as an advanced magnetic resonance imaging modality,utilizes the phase information in magnetic resonance imaging to achieve an accurate quantitative assessment of iron content in brain tissue.This paper reviews the imaging principle of QSM technology and its potential value and application prospects in the diagnosis of PD,aiming to provide new insights for PD diagnosis.

关 键 词：帕金森病 定量磁化率成像 磁共振成像 铁沉积 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.16[医药卫生—诊断学]