中枢神经系统疾病与脑淋巴系统的研究进展  

Research progress in central nervous system diseases and the brain lymphatic system

作　　者：贺曦 陈莉[1] 王唯成[1] HE Xi;CHEN Li;WANG Weicheng(Department of Radiology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院放射科,南充637000

出　　处：《磁共振成像》2025年第3期127-132,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家临床重点专科建设项目(编号[:2023]87);南充市校科技战略合作专项(编号:20SXZRKX0011)。

摘　　要：传统观念认为,中枢神经系统不存在清除代谢废物的淋巴系统。近年来,随着对大脑代谢废物清除的深入研究,人们发现中枢神经系统中存在淋巴系统,包括胶质淋巴系统和脑膜淋巴管,并在动物及人体实验中得到了证实。本文通过回顾脑淋巴系统的结构和功能、影响因素及检查方法,并综述了该系统在多种中枢神经系统疾病中的研究进展,旨在为疾病的神经影像诊断和治疗提供新思路。Traditional views held that the central nervous system(CNS) lacks a lymphatic system for metabolic waste clearance.However,recent advances in brain waste clearance research have revealed the existence of specialized lymphatic structures within CNS,namely the glymphatic system and meningeal lymphatic vessels.These discoveries have been validated through both animal models and human studies.This systematically article reviews the anatomical organization and physiological functions of the brain's lymphatic system,examines factors modulating its activity,and evaluates current detection methodologies.Furthermore,we synthesize emerging evidence highlighting the involvement of this system in the pathogenesis of various CNS disorders,with the goal of adwancing neuroimaging strategies and therapeutic interventions for these conditions.

关 键 词：中枢神经系统疾病 胶质淋巴系统 脑膜淋巴管 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R741[医药卫生—诊断学] R551.2[医药卫生—临床医学]