多发性硬化胶质淋巴系统的研究进展  

Research progress in glymphatic system of multiple sclerosis

作　　者：宋元君 赵鹤 高阳[2] SONG Yuanjun;ZHAO He;GAO Yang(Inner Mongolia Medical University,Hohhot 010000,China;Department of Imaging Diagnostic,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学,呼和浩特010000 [2]内蒙古医科大学附属医院影像诊断科,呼和浩特010050

出　　处：《磁共振成像》2025年第3期133-137,共5页Chinese Journal of Magnetic Resonance Imaging

摘　　要：多发性硬化(multiple sclerosis,MS)是一种中枢神经系统的慢性炎性脱髓鞘疾病,伴随神经功能损伤,其具体病理机制尚不明了。近年来胶质淋巴系统(glymphatic system,GS)在MS中的作用引起广泛关注,GS功能可能与代谢废物堆积和神经炎症反应有关,并进一步影响患者的认知功能。本综述回顾了MS的GS相关研究,聚焦其与认知损伤的关系,以期为MS的病理生理过程及诊断、治疗提供新的见解。Multiple sclerosis(MS) is a chronic inflammatory demyelinating disease of the central nervous system with neurological impairment,and its specific pathological mechanism is unknown.Recently,there has been a lot of concern about the role of the glymphatic system(GS) in MS,which may be associated with metabolic waste accumulation and neuroinflammatory responses,and further affect patients' cognitive function.This review reviews the GS-related studies of MS and focuses on its relationship with cognitive impairment,in order to provide new insights into the pathophysiological process,diagnosis,and treatment of MS.

关 键 词：多发性硬化 胶质淋巴系统 认知 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R744.51[医药卫生—诊断学]