乳腺癌化疗所致周围神经病变诱发中枢异常的多模态MRI研究进展  

Progress of multimodal MRI research on central abnormalities induced by chemotherapy-induced peripheral neuropathy in breast cancer

作　　者：范宇捷 廖海 FAN Yujie;LIAO Hai(Department of Radiology,Guangxi Medical University Cancer Hospital,Nanning 530021,China)

机构地区：[1]广西医科大学附属肿瘤医院放射科,南宁530021

出　　处：《磁共振成像》2025年第3期138-142,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:81960570)。

摘　　要：化疗所致周围神经病变(chemotherapy-induced peripheral neuropathy,CIPN)是乳腺癌患者常见不良反应之一,其不仅影响外周神经,还可能通过复杂的神经-免疫-内分泌途径导致中枢神经系统的功能与结构异常。近年来,随着多模态MRI技术的快速发展,功能MRI (functional MRI,fMRI)、结构MRI(structural MRI,sMRI)、扩散张量成像(diffusion tensor imaging,DTI)、灌注加权成像(perfusion-weighted imaging,PWI)、动脉自旋标记(arterial spin labeling,ASL)、磁共振波谱(magnetic resonance spectroscopy,MRS)等影像学方法,为研究CIPN诱发中枢异常的病变机制提供了新的视角,能够全面揭示脑微结构变化与功能网络重组。本文综述了多模态MRI技术在乳腺癌CIPN诱发中枢异常研究中的临床应用及其潜在价值,为该疾病的早期诊断与精准防治提供了技术参考。Chemotherapy-induced peripheral neuropathy(CIPN) is a common adverse reaction in breast cancer patients,affecting not only the peripheral nervous system but also leading to structural and functional abnormalities in the central nervous system through complex neuro-immune-endocrine pathways.In recent years,with the rapid development of multimodal MRI,functional MRI(fMRI),structural MRI(sMRI),diffusion tensor imaging(DTI),perfusion-weighted imaging(PWI),arterial spin labeling(ASL),and magnetic resonance spectroscopy(MRS) have provided new insights into the etiopathogenesis of CIPN-induced central abnormalities.These methods enable a comprehensive assessment of brain microstructural changes and functional network reorganization.This review summarizes the clinical applications and potential value of multimodal MRI techniques in studying central abnormalities induced by CIPN in breast cancer patients,providing a technical reference for early diagnosis and precise prevention and treatment of the disease.

关 键 词：乳腺癌 化疗所致周围神经病变 磁共振成像 中枢异常 病变机制 

分 类 号：R445.2[医药卫生—影像医学与核医学] R745[医药卫生—诊断学]