磁共振成像在结缔组织病相关间质性肺病中的应用现状  

Current status of magnetic resonance imaging in connective tissue disease-associated interstitial lung disease

作　　者：杨腾月 蒲豆豆 于楠 YANG Tengyue;PU Doudou;YU Nan(School of Medical Technology,Shaanxi University of Chinese Medicine,Xianyang 712046,China;Department of Medical Imaging,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)

机构地区：[1]陕西中医药大学医学技术学院,咸阳712046 [2]陕西中医药大学附属医院医学影像科,咸阳712000

出　　处：《磁共振成像》2025年第3期167-172,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：陕西省教育厅青年创新团队科研计划项目(编号:23JP036)。

摘　　要：高分辨率计算机断层扫描(high-resolution computed tomography,HRCT)作为结缔组织病相关间质性肺病(connective tissue disease-interstitial lung disease,CTD-ILD)诊断的“金标准”,由于存在辐射暴露问题,在疾病长期动态监测中的应用受到了限制。磁共振成像(magnetic resonance imaging,MRI)作为一种无辐射、多参数成像技术,能够提供肺部通气、灌注、组织硬度和生物力学特性的定量信息,无创性地评估CTD-ILD的病理变化和疾病进展。本文系统综述了MRI在CTD-ILD中的应用现状,重点分析了超短回波序列(ultrashort echo time,UTE)、磁共振弹性成像(magnetic resonance elastography,MRE)、动态对比增强MRI(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)及超极化^(129)Xe MRI(hyperpolarized^(129)Xe magnetic resonance imaging,HP^(129)Xe MRI)等技术在CTD-ILD诊断、分型及疗效评估中的潜力,并探讨了当前技术局限性与未来发展方向,以期为优化CTD-ILD的临床管理提供新思路。High-resolution computed tomography (HRCT),regarded as the"gold standard"for the diagnosis of connective tissue disease-interstitial lung disease (CTD-ILD),due to the problem of radiation exposure,its application in the long-term dynamic monitoring of diseases is restricted.Magnetic resonance imaging (MRI),a non-radiation and multi-parameter imaging technology,can provide quantitative information on lung ventilation,perfusion,tissue hardness,and biomechanical properties.It enables the non-invasive assessment of pathological changes and disease progression in CTD-ILD.This article systematically reviews the current application status of MRI in CTD-ILD.It focuses on analyzing the potential of techniques such as ultrashort echo time (UTE),Magnetic resonance elastography (MRE),dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI),and hyperpolarized ~(129)Xe magnetic resonance imaging (HP ~(129)Xe MRI) in the diagnosis,classification,and efficacy evaluation of CTD-ILD.Moreover,it explores the limitations of current technologies and future development directions,aiming to provide new ideas for optimizing the clinical management of CTD-ILD.

关 键 词：结缔组织病相关间质性肺病 磁共振成像 超短回波时间序列 超极化^(129)Xe磁共振成像 分子成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R563[医药卫生—诊断学]