酰胺质子转移成像在乳腺癌诊疗中的应用进展  

Advances in amide proton transfer imaging for breast cancer diagnosis and treatment

作　　者：王世隆 田志玮 毛锡金[1,2] WANG Shilong;TIAN Zhiwei;MAO Xijin(Department of Radiology,Binzhou Medical University Hospital,Binzhou 256600,China;School of Medical Imaging,Binzhou Medical University,Yantai 264003,China)

机构地区：[1]滨州医学院附属医院放射科,滨州256600 [2]滨州医学院医学影像学院,烟台264003

出　　处：《磁共振成像》2025年第3期178-183,195,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：山东省医药卫生科技发展项目(编号:202309011243)。

摘　　要：乳腺癌作为女性发病率最高的恶性肿瘤,其发病率和死亡率持续攀升。影像学检查在疾病诊断、病情监测及预后评估等方面具有不可替代的重要作用。近年来,酰胺质子转移成像(amide proton transfer,APT)因其能从分子层面反映疾病生化特性,被广泛应用于乳腺癌的诊断与治疗。本文综述了APT成像在乳腺癌诊断、组织病理指标的相关性预测以及疗效评估等方面的应用进展,为乳腺癌的分子成像提供了新视角。Breast cancer,as the most prevalent malignancy in women,has seen its incidence and mortality rates steadily increasing.Imaging examinations play an indispensable role in disease diagnosis,disease monitoring,and prognostic evaluation.In recent years,amide proton transfer(APT) imaging,owing to its capability to provide insights into the biochemical characteristics of diseases at the molecular level,has found extensive applications in the diagnosis and treatment of breast cancer.This review summarizes the advances in the application of APT imaging in breast cancer diagnosis,correlation assessment with histopathological parameters,and therapeutic response evaluation,offering novel perspectives for molecular imaging in breast cancer.

关 键 词：磁共振成像 酰胺质子转移成像 乳腺癌 化学交换饱和转移成像 分子成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]