时间依赖扩散MRI在肿瘤诊断及疗效评估中的研究进展  

Advances in time-dependent diffusion MRI for tumor diagnosis and treatment response evaluation

作　　者：李燕婉 陈晓丽[2] LI Yanwan;CHEN Xiaoli(School of Medicine University of Electronic Science and Technology of China,Chengdu 610051,China;Department of Radiology,Sichuan Clinical Research Center for Cancer,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,Affiliated Cancer Hospital of University of Electronic Science and Technology of China,Chengdu 610041,China)

机构地区：[1]电子科技大学医学院,成都610051 [2]四川省肿瘤临床医学研究中心,四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学附属肿瘤医院影像科,成都610041

出　　处：《磁共振成像》2025年第3期228-234,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：四川省肿瘤医院优秀青年基金(编号:YB2025018);四川省国际科技创新合作项目(编号:2020YFH0166)。

摘　　要：时间依赖扩散MRI(time-dependent diffusion MRI,TDD-MRI)是新型的扩散加权成像技术,通过数学模型拟合基于振荡梯度回波和脉冲梯度回波序列获取的扩散MRI数据,可以非侵入性地量化细胞直径、细胞密度等肿瘤细胞微观结构参数。TDD-MRI技术在肿瘤中研究较为广泛,例如区分肿瘤的良恶性、评估肿瘤分期、预测侵袭性等方面,并展现出良好的诊断性能。因此,本文将对TDD-MRI技术在头颈部肿瘤、前列腺肿瘤及乳腺肿瘤等肿瘤中的临床研究价值及应用前景进行综述,以期为TDD-MRI技术的研究工作提供参考。Time-dependent diffusion magnetic resonance imaging(TDD-MRI) is an emerging diffusion-weighted imaging technique,which can non-invasively quantify neoplastic cellular microstructural parameters such as cell diameter and cellularity,through established mathematical models fitting diffusion MRI data from using of oscillating gradient spin echo and pulsed gradient spin echo.TDD-MRI has been extensively investigated in oncology,including its application in differentiating benign from malignant tumors,evaluating tumor staging,and predicting tumor invasiveness,thereby demonstrating promising diagnostic performance.Consequently,this review aims to summarize the clinical research value and potential applications of TDD-MRI in tumors such as those of the head and neck,prostate,and breast,with the goal of providing insights for future research.

关 键 词：磁共振成像 扩散加权成像 时间依赖扩散加权成像 振荡梯度回波序列 肿瘤 

分 类 号：R445.2[医药卫生—影像医学与核医学]