冠心病患者TyG指数及NT-proBNP、载脂蛋白水平与冠状动脉狭窄程度的相关性分析  

Correlations of TyG index,NT-proBNP and apolipoproteins with severity of coronary artery stenosis in patients with coronary artery disease

作　　者：翟海杰 彭庚[1] 胡新荣[1] Zhai Haijie;Peng Geng;Hu Xinrong(Department of Cardiovascular Medicine,Luohe Central Hospital,Luohe 462300,China)

机构地区：[1]漯河市中心医院心血管内科,漯河462300

出　　处：《中国实用医刊》2025年第4期32-35,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析冠心病患者三酰甘油葡萄糖乘积(TyG)指数及氨基末端脑钠肽前体(NT-proBNP)、载脂蛋白水平与冠状动脉狭窄程度的相关性。方法回顾性研究。抽取2022年5月至2024年5月漯河市中心医院收治的120例冠心病患者,根据冠状动脉Gensini积分分为轻度狭窄组(39例,Gensini积分<20分)、中度狭窄组(46例,20分≤Gensini积分<45分)、重度狭窄组(35例,Gensini积分≥45分)。检测3组患者三酰甘油、空腹血糖、NT-proBNP、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)水平,并计算TyG指数。比较3组TyG指数、NT-proBNP、ApoA、ApoB水平。分析冠状动脉狭窄程度的危险因素,分析TyG指数、NT-proBNP、ApoA、ApoB与冠心病患者冠状动脉狭窄程度的相关性。结果中度狭窄组和重度狭窄组TyG指数、NT-proBNP、ApoB水平高于轻度狭窄组,ApoA水平低于轻度狭窄组(P<0.05)。重度狭窄组TyG指数、NT-proBNP、ApoB水平高于中度狭窄组,ApoA水平低于中度狭窄组(P<0.05)。Logistic回归分析结果显示,TyG指数高、NT-proBNP高、ApoB高、ApoA低是影响冠状动脉狭窄程度的危险因素(P<0.05)。Pearson分析结果显示,TyG指数(r=0.48)、NT-proBNP(r=0.63)、ApoB(r=0.57)与冠状动脉狭窄程度呈正相关(P<0.05),ApoA(r=-0.40)与冠状动脉狭窄程度负正相关(P<0.05)。结论TyG指数、NT-proBNP、ApoA、ApoB与冠心病患者冠状动脉狭窄程度存在明显关联性,冠状动脉狭窄程度越重,TyG指数、NT-proBNP、ApoB水平越高,且ApoA水平越低。ObjectiveTo analyze the correlations of triglyceride-glucose(TyG)index,amino-terminal pro-brain natriuretic peptide(NT-proBNP)and apolipoproteins with the degree of coronary artery stenosis in patients with coronary heart disease.MethodsA total of 120 patients with coronary heart disease treated in Luohe Central Hospital from May 2022 to May 2024 were selected for the retrospective study.According to the coronary Gensini score,the selected patients were divided in to the mild stenosis group(39 cases,Gensini score<20),the moderate stenosis group(46 cases,20≤Gensini score<45)and the severe stenosis group(35 cases,Gensini score≥45).The levels of triglyceride,fasting glucose,NT-proBNP,apolipoprotein A(ApoA)and apolipoprotein B(ApoB)in the three groups were detected,an then the TyG index was calculated.The levels of TyG index,NT-proBNP,ApoA and ApoB of the 3 groups were compared to analyze the risk factors for degree of coronary artery stenosis.The correlations of TyG index,NT-proBNP,ApoA and ApoB with coronary artery stenosis were analyzed.ResultsCompared with the mild stenosis group,the moderate stenosis group and the severe stenosis group had higher levels of TyG index,NT-proBNP and ApoB,but had lower level of ApoA(P<0.05).Compared with the moderate stenosis group,the TyG index,NT-proBNP and ApoB levels in the severe stenosis group were higher,and the ApoA level in the severe stenosis group was lower(P<0.05).Logistic regression analysis showed that high TyG index,high NT-proBNP,high ApoB and low ApoA were risk factors affecting the degree of coronary artery stenosis(P<0.05).Pearson analysis revealed that TyG index(r=0.48),NT-proBNP(r=0.63),ApoB(r=0.57)were positively correlated with the degree of coronary artery stenosis(P<0.05),while ApoA(r=-0.40)was negatively correlated with the degree of coronary artery stenosis(P<0.05).ConclusionsTyG index,NT-proBNP,ApoA and ApoB have correlations with the degree of coronary artery stenosis in patients with coronary heart disease.With aggravation of coronary artery stenosi

关 键 词：冠心病 冠状动脉狭窄程度 三酰甘油葡萄糖乘积指数 氨基末端脑钠肽前体 载脂蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]