注射用胰蛋白酶联合银离子藻酸盐抗菌敷料治疗老年脑卒中后Ⅱ期压疮的临床观察  

Observation of trypsin for injection combined with silver ion alginate antibacterial dressing in the treatment of stage II pressure ulcer after stroke in the elderly

作　　者：臧鑫亚 孔羽 张冉[1] 王拴刘 杨丽[1] 王梦[1] 程磊 徐东雪 Zang Xinya;Kong Yu;Zhang Ran;Wang Shuan liu;Yang Li;Wang Meng;Cheng Lei;Xu Dongxue(Department of General ICU,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院综合ICU,郑州450000

出　　处：《中国实用医刊》2025年第4期60-63,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨注射用胰蛋白酶联合银离子藻酸盐抗菌敷料对脑卒中压疮(Ⅱ期)老年患者的治疗效果。方法队列研究。抽取2021年3月至2024年3月郑州大学第一附属医院收治的脑卒中压疮(Ⅱ期)老年患者86例,按双色球法随机分为对照组与观察组,每组43例。对照组采用银离子藻酸盐抗菌敷料治疗,观察组采用银离子藻酸盐抗菌敷料联合注射用胰蛋白酶治疗。比较两组临床疗效、换药次数、压疮创面愈合时间、压疮部位血流灌注量、压疮部位疼痛情况[视觉模拟评分法(VAS)评分]、压疮部位愈合情况[压疮愈合计分量表(PUSH)评分]及炎症因子水平。结果观察组总有效率(97.67%,42/43)高于对照组(81.40%,35/43),P<0.05。治疗后,观察组换药次数少于对照组,压疮创面愈合时间短于对照组(P<0.05)。治疗后,观察组压疮部位血流灌注量高于对照组,VAS评分、PUSH评分及炎症因子水平均低于对照组(P均<0.05)。结论脑卒中压疮(Ⅱ期)老年患者采用注射用胰蛋白酶联合银离子藻酸盐抗菌敷料治疗,可以降低其炎症因子水平及压疮部位疼痛程度,提升血流灌注量,改善压疮创面愈合效果,减少换药次数并缩短压疮愈合时间。ObjectiveTo investigate the therapeutic effect of trypsin for injection combined with silver ion alginate antibacterial dressing on elderly patients with stroke pressure ulcer(stage II).MethodsA total of 86 elderly patients with stroke pressure ulcer(stage II)admitted to the First Affiliated Hospital of Zhengzhou University from March 2021 to March 2024 were selected for the cohort study,and they were divided into the control group and the observation group according to the random bi-color chromosphere method,with 43 cases in each group.The control group was treated with silver ion alginate antibacterial dressing,and the observation group was treated with silver ion alginate antibacterial dressing combined with trypsin for injection.The clinical efficacy,frequency of dressing changes,wound healing time,blood perfusion volume at the pressure ulcer site,pain at the pressure ulcer site assessed by visual analogue scale(VAS)score,healing at the pressure ulcer site assessed by pressure ulcer scale for healing(PUSH)score and inflammatory factors levels were compared between the two groups.ResultsThe total effective rate of the observation group(97.67%,42/43)was higher than that of the control group(81.40%,35/43),P<0.05.After treatment,the frequency of dressing changes in the observation group was less than that in the control group,and the wound healing time was shorter than that in the control group(P<0.05).After treatment,the blood perfusion volume at the pressure sore site in the observation group was higher than that in the control group,while the VAS score,PUSH score and inflammatory factors levels in the observation group were lower than those in the control group(all P<0.05).ConclusionsTrypsin for injection combined with silver ion alginate antibacterial dressing in the treatment of elderly stroke patients with pressure ulcer(stage II)could reduce the levels of inflammatory factors and the pain of pressure ulcer,increase blood perfusion volume,improve the healing effect of pressure ulcer wounds,reduce the freque

关 键 词：脑卒中 Ⅱ期压疮 老年 注射用胰蛋白酶 银离子藻酸盐抗菌敷料 

分 类 号：R473.5[医药卫生—护理学]