舒利迭吸入治疗老年慢性阻塞性肺疾病的效果及对肺功能指标的影响  

Therapeutic effect of inhaled seretide on elderly patients with chronic obstructive pulmonary disease and its impact on lung function indicators

作　　者：赵鹏[1] 冯敏娟 Zhao Peng;Feng Minjuan(Emergency Center,the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712099,China;Department of Respiratory and Critical Care Medicine,Xianyang Hospital of Yan’an University,Xianyang 712000,China)

机构地区：[1]陕西中医药大学第二附属医院急救中心,咸阳712099 [2]延安大学咸阳医院呼吸与危重症医学科,咸阳712000

出　　处：《中国实用医刊》2025年第4期86-89,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨舒利迭吸入治疗老年慢性阻塞性肺疾病(COPD)的临床效果。方法队列研究。抽取2021年11月至2024年3月陕西中医药大学第二附属医院收治的老年COPD患者109例,采用信封法将其分为对照组(54例,常规治疗)和研究组(55例,在常规治疗基础上加用舒利迭治疗)。记录并比较两组治疗前后血气分析指标及肺功能指标、用药相关性不良反应。结果治疗前,两组血气分析指标比较差异未见统计学意义(P>0.05);治疗后,两组动脉血氧分压(PaO_(2))高于治疗前,动脉血二氧化碳分压(PaCO_(2))低于治疗前,且研究组PaO_(2)高于对照组,研究组PaCO_(2)低于对照组(P<0.05)。治疗前,两组肺功能指标比较差异未见统计学意义(P>0.05);治疗后,两组最大通气量、深吸气量高于治疗前,且研究组高于对照组(P<0.05)。两组用药相关性不良反应发生率比较,差异未见统计学意义(P>0.05)。结论应用舒利迭有利于改善老年COPD患者肺功能、血气分析指标,且有一定安全性。ObjectiveTo investigate the clinical effect of inhaled seretide in the treatment of elderly patients with chronic obstructive pulmonary disease(COPD).MethodsA total of 109 elderly COPD patients admitted to the Second Affiliated Hospital of Shaanxi University of Chinese Medicine from November 2021 to March 2024 were selected for the cohort study.And they were divided into the control group(54 cases,treated by conventional treatment)and the study group(55 cases,treated with seretide based on conventional treatment)by the envelope method.The blood gas analysis indexes and lung function indexes of the two groups were compared before and after treatment.And drug-related adverse reactions of the two groups were compared.ResultsBefore treatment,there was no significant difference in blood gas analysis indexes between the two groups(P>0.05).After treatment,the arterial partial pressure of oxygen(PaO_(2))in the two groups increased,and the partial pressure of arterial carbon dioxide(PaCO_(2))in the two groups decreased(P<0.05);moreover,and the study group had higher PaO_(2)and lower PaCO_(2)compared with the control group after treatment(P<0.05).Before treatment,there was no significant difference in pulmonary function indexes between the two groups(P>0.05).After treatment,the maximum ventilation and deep inspiratory volume of the two groups were higher than those before treatment,moreover,the study group had higher maximum ventilation and deep inspiratory volume than the control group(P<0.05).There was no significant difference in the incidence of drug-related adverse reactions between the two groups(P>0.05).ConclusionsThe application of seretide is conductive to improving lung function and blood gas analysis indexes in elderly patients with COPD,with certain safety.

关 键 词：慢性阻塞性肺疾病 老年 舒利迭 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]