葡萄糖酸锌辅助治疗儿童轮状病毒性肠炎的效果观察  

Effect of zinc gluconate in adjunctive therapy on children with rotavirus enteritis

作　　者：雷杰喻 拓荣荣 Lei Jieyu;Tuo Rongrong(Department of Pharmacy,Yan’an University Affiliated Hospital,Yan’an 716000,China;Department of Pediatrics,Yan’an Branch of the Third Hospital of Peking University,Yan’an Traditional Chinese Medicine Hospital,Yan’an 716000,China)

机构地区：[1]延安大学附属医院药剂科,延安716000 [2]延安市中医医院、北京大学第三医院延安分院儿科,延安716000

出　　处：《中国实用医刊》2025年第4期93-96,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨葡萄糖酸锌辅助治疗儿童轮状病毒性肠炎的效果。方法队列研究。抽取2021年1月至2024年1月延安大学附属医院和延安市中医医院收治的94例轮状病毒性肠炎患儿,按照治疗方法分为对照组和观察组,每组47例。对照组接受常规药物治疗,观察组在此基础上加用葡萄糖酸锌。比较两组的治疗效果、临床症状、炎性因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)以及肿瘤坏死因子-α(TNF-α)]水平、免疫球蛋白[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)]水平及不良反应发生率。结果观察组总有效率(95.74%,45/47)高于对照组(78.72%,37/47),P<0.05。观察组发热持续时间、腹泻持续时间、呕吐持续时间均短于对照组(P均<0.05)。治疗后,观察组IL-6、IL-8、TNF-α水平均低于对照组(P均<0.05),IgA、IgG水平均高于对照组(P均<0.05)。观察组不良反应发生率(8.51%,4/47)低于对照组(14.89%,7/47),P<0.05。结论葡葡萄糖酸锌辅助治疗儿童轮状病毒性肠炎,能够提高治疗效果,改善临床症状,调节炎性因子及免疫球蛋白水平,降低不良反应发生率。ObjectiveTo investigate the effect of zinc gluconate in the adjunctive treatment of rotavirus enteritis in children.MethodsA total of 94 children with rotavirus enteritis admitted to Yan’an University Affiliated Hospital and Yan’an Traditional Chinese Medicine Hospital from January 2021 to January 2024 were selected for the cohort study.And they were divided into a control group and an observation group according to the treatment method,with 47 cases in each group.The control group received conventional drug therapy,while the observation group received zinc gluconate as adjunctive therapy based on the treatment of the control group.The therapeutic effect,clinical symptoms,inflammatory factors,including interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),immunoglobulins,including immunoglobulin A(IgA)and immunoglobulin G(IgG),and incidence of adverse reactions were compared between the two groups.ResultsThe total effective rate in the observation group(95.74%,45/47)was higher than that in the control group(78.72%,37/47),P<0.05.The duration of fever,diarrhea,and vomiting in the observation group were shorter than those in the control group(all P<0.05).After treatment,the levels of IL-6,IL-8,and TNF-αin the observation group were lower than those in the control group(all P<0.05),while the levels of IgA and IgG in the observation group were higher than those in the control group(both P<0.05).The incidence of adverse reactions in the observation group(8.51%,4/47)was lower than that in the control group(14.89%,7/47),P<0.05.ConclusionsZinc gluconate as an adjuvant therapy for children with rotavirus enteritis can improve treatment efficacy,alleviate clinical symptoms,regulate inflammatory factors and immunoglobulins levels,and reduce the incidence of adverse reactions.

关 键 词：肠炎 轮状病毒 葡萄糖酸锌 治疗效果 炎性因子 免疫球蛋白 

分 类 号：R725.7[医药卫生—儿科]