长效胰岛素联合超短效胰岛素治疗妊娠期糖尿病的效果研究  

Effect of long-acting insulin combined with ultra-short-acting insulin in the treatment of gestational diabetes mellitus

作　　者：孟柳 岳静静 Meng Liu;Yue Jingjing(Department of Obstetrics and Gynecology,Jiaozuo Maternal and Child Health Hospital,Jiaozuo 454000,China)

机构地区：[1]焦作市妇幼保健院产科,焦作454000

出　　处：《中国实用医刊》2025年第4期97-100,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨长效胰岛素联合超短效胰岛素治疗妊娠期糖尿病(GDM)的疗效及安全性。方法队列研究。抽取2023年1月至2023年10月焦作市妇幼保健院收治的96例GDM患者,采用随机数字表法分成对照组和研究组,每组48例。对照组予以超短效胰岛素控制血糖,研究组予以长效胰岛素联合超短效胰岛素控制血糖。比较两组血糖与胰岛素水平变化、血糖控制情况、不良妊娠结局发生率及新生儿不良结局发生率。结果用药后,两组空腹血糖、餐后2 h血糖及空腹胰岛素水平均低于用药前,且研究组低于对照组(P<0.05);研究组血糖水平达标时间短于对照组,24 h最大血糖波动幅度小于对照组,低血糖发生率低于对照组(P<0.05)。研究组不良妊娠结局总发生率(14.58%,7/48)低于对照组(33.33%,16/48),P<0.05。研究组新生儿不良结局发生率(18.75%,9/48)低于对照组(39.58%,19/48),P<0.05。结论长效胰岛素联合超短效胰岛素治疗GDM在提高血糖控制效果、降低不良妊娠和新生儿结局发生率方面具有明显优势。ObjectiveTo investigate the efficacy and safety of long-acting insulin combined with ultra-short-acting insulin in the treatment of gestational diabetes mellitus(GDM).MethodsNinety-six GDM patients admitted to Jiaozuo Maternal and Child Health Hospital from January 2023 to October 2023 were selected for the cohort study.All of them were divided into into control group and study group according to random number table method,with 48 cases in each group.The control group was given ultra-short-acting insulin for blood sugar control,while the study group was given long-acting insulin and ultra short-acting insulin for blood sugar control.The changes of blood glucose and insulin levels,blood glucose control,incidence of adverse pregnancy outcomes,and the incidence of adverse neonatal outcome of the two groups were compared.ResultsFasting blood glucose,2-hour postprandial blood glucose and fasting insulin levels in both groups decreased significantly after taking the drug,and the levels in the study group were lower than those in the control group(P<0.05).The time to reach the standard of blood sugar level in the study group was shorter than that in the control group,the largest amplitude of glycemic excursion in 24 hours was smaller than that in the control group,and the incidence of hypoglycemia was lower than that in the control group(P<0.05).The total incidence of adverse pregnancy outcome in the study group(14.58%,7/48)was lower than that in the control group(33.33%,16/48),P<0.05.The incidence of adverse neonatal outcome in the study group(18.75%,9/48)was lower than that in the control group(39.58%,19/48),P<0.05.ConclusionsLong-acting insulin combined with ultra-short-acting insulin in the treatment of GDM has obvious advantages of improving blood glucose control,reducing the incidences of adverse pregnancy and neonatal outcome.

关 键 词：胰岛素 妊娠期糖尿病 疗效 安全性 

分 类 号：R714.256[医药卫生—妇产科学]