单细胞RNA测序解析子宫内膜异位症血管生成机制  

Single-Cell RNA Sequencing Analysis of the Angiogenesis Mechanism in Endometriosis

作　　者：曹秀蓉 周文柏[1] 范香 王逸斐 朱鹏峰(审校)[1] CAO Xiu-rong;ZHOU Wen-bai;FAN Xiang;WANG Yi-fei;ZHU Peng-feng(Changzhou Maternity and Child Health Care Hospital,Changzhou Medical Center,Nanjing Medical University,Changzhou 213000,Jiangsu Province,China)

机构地区：[1]南京医科大学常州医学中心,常州市妇幼保健院,213000

出　　处：《国际妇产科学杂志》2025年第2期199-205,共7页Journal of International Obstetrics and Gynecology

基　　金：常州市妇幼保健院科研项目(YJ202408);常州市“十四五”卫生健康高层次人才培养工程-拔尖人才(2022CZBJ085);江苏省第六期“333高层次人才培养工程”第三层次(2022 3-4-162)。

摘　　要：子宫内膜异位症(endometriosis,EMs)作为一种发病机制尚不明确的疾病,亟需借助新兴技术深入阐明其发病过程。将单细胞RNA测序(single-cell RNA sequencing,scRNA-seq)技术应用在EMs研究中,可以从单个细胞信息出发,获取EMs相关的细胞分化、发展、演化及细胞间相互作用等完备信息,帮助对EMs发病机制形成更全面的认知。综述兴起的scRNA-seq技术以及近年来通过scRNA-seq获得的与EMs血管生成领域相关的研究进展。从细胞功能紊乱、免疫失衡等多个影响血管生成的角度出发,探讨EMs相关细胞与血管生成、免疫微环境改变、激素反应性、纤维化等疾病生物学机制之间的关系,以期为进一步探究EMs中血管生成发生机制以及寻找新的治疗靶点提供新思路。Endometriosis(EMs),as a disease with an unclear etiology,urgent to clarify its pathogenesis with the help of emerging new technologies.The application of single-cell RNA sequencing(scRNA-seq)technology in the research of EMs can obtain complete information about the differentiation,development,evolution,and intercellular interactions from the perspective of individual cells,to help to form a more comprehensive understanding of the pathogenic mechanism of EMs.This article reviews the emerging scRNA-seq technology and the research progress related to angiogenesis in EMs obtained through scRNA-seq in recent years.From multiple perspectives that affect angiogenesis,such as cellular dysfunction and immune imbalance,this article details the relationship between the associated cells of EMs and disease biological mechanisms such as angiogenesis,immune microenvironment changes,hormone responsiveness,and fibrosis,provides new ideas for exploring the pathogenesis of angiogenesis in EMs and finds new therapeutic targets.

关 键 词：序列分析 RNA 高通量核苷酸序列分析 子宫内膜异位症 异质性 单细胞RNA测序 血管生成 

分 类 号：R711.71[医药卫生—妇产科学]