甘油三酯-葡萄糖指数与急性心肌梗死后新发心房颤动的相关性  

Correlation between triglyceride-glucose index and new-onset atrial fibrillation after acute myocardial infarction

作　　者：陈硕 李朋[1] 徐建辉 方梦 CHEN Shuo;LI Peng;XU Jianhui;FANG Meng(The Second Department of Cardiology,Xiaogan Hospital Affiliated to Wuhan University of Science and Technology,the Central Hospital of Xiaogan,Hubei Province,Xiaogan432000,China)

机构地区：[1]武汉科技大学附属孝感医院、湖北省孝感市中心医院心内二科,湖北孝感432000

出　　处：《中国当代医药》2025年第10期69-73,共5页China Modern Medicine

基　　金：湖北省孝感市自然科学计划项目(XGKJ2023010017)。

摘　　要：目的探讨甘油三酯-葡萄糖(TyG)指数与急性心肌梗死(AMI)后新发心房颤动(NOAF)患者的相关性及预测价值。方法选取2021年5月至2022年2月孝感市中心医院收治的230例AMI患者作为研究对象,根据AMI后是否发生NOAF将患者分为研究组(发生NOAF,共25例)和对照组(无NOAF,共205例)。收集两组患者的临床特征,如年龄、性别、吸烟史、高血压病史、糖尿病史、体重指数(BMI)等;实验室指标,如血清肌酐(Cr)、糖化血红蛋白(HbA1c)、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、TyG指数等,比较两组患者临床特征及实验室指标的差异,采用多因素logistic回归分析评价AMI后NOAF的危险因素;采用Spearman相关性分析及ROC曲线评估TyG指数与AMI后NOAF的相关性及预测价值。结果单因素分析结果显示,NOAF与患者的高血压病史比例、HbA1c、FBG、TC、TG、TyG指数有关,差异有统计学意义(P<0.05);logistic回归模型进行多因素分析结果显示,FBG(β=2.708,OR=14.998,95%CI:4.115~54.661)、TC(β=1.232,OR=3.429,95%CI:1.246~9.433)、TyG指数(β=1.063,OR=2.896,95%CI:1.367~6.134)是AMI后NOAF的独立危险因素(P<0.05);Spearman相关性分析结果显示,TyG指数与AMI后NOAF呈正相关(r=0.428,P<0.001);ROC曲线分析结果显示,TyG指数预测AMI后NOAF的AUC为0.897(95%CI:0.843~0.952,P<0.001),灵敏度和特异度分别为77.9%和85.9%。结论TyG指数与AMI后NOAF呈正相关。TyG指数是AMI后NOAF的独立危险因素,且TyG指数对于AMI后NOAF有一定的预测价值。Objective To investigate the correlation and predictive value of triglyceride-glucose(TyG)index in patients with new-onset atrial fibrillation(NOAF)after acute myocardial infarction(AMI).Methods A total of 230 patients with AMI admitted to the Central Hospital of Xiaogan from May 2021 to February 2022 were selected as the research objects.According to whether NOAF occurred after AMI,the patients were divided into study group(25 cases with NOAF)and control group(205 cases without NOAF).Clinical characteristics,such as age,sex,smoking history,history of hypertension,history of diabetes,body mass index(BMI),and laboratory indicators,such as serum creatinine(Cr),glycosylated hemoglobin(HbA1c),fasting blood glucose(FBG),total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),TyG index,etc.were collected.Clinical characteristics and laboratory indicators were compared between the two groups of patients.Multivariate logistic regression analysis was used to evaluate the risk factors of NOAF after AMI.Spearman correlation analysis and ROC curve were used to evaluate the correlation and predictive value of TyG index with NOAF after AMI.Results Univariate analysis showed that NOAF was correlated with the proportion of hypertension history,HbA1c,FBG,TC,TG and TyG index,and the differences were statistically significant(P<0.05).Multivariate analysis of logistic regression model showed that FBG(β=2.708,OR=14.998,95%CI:4.115-54.661),TC(β=1.232,OR=3.429,95%CI:1.246-9.433)and TyG index(β=1.063,OR=2.896,95%CI:1.367-6.134)were independent risk factors for NOAF after AMI(P<0.05).Spearman correlation analysis showed that TyG index was positively correlated with NOAF after AMI(r=0.428,P<0.001).ROC curve analysis showed that the AUC of NOAF predicted by TyG index after AMI was 0.897(95%CI:0.843-0.952,P<0.001),and the sensitivity and specificity were 77.9%and 85.9%,respectively.Conclusion TyG index is positively correlated with NOAF after AMI.TyG index is an independent risk factor for NOAF after AMI,and TyG index has cer

关 键 词：甘油三酯-葡萄糖指数 急性心肌梗死 新发心房颤动 危险因素 预测价值 

分 类 号：R541.75[医药卫生—心血管疾病]