难治性内耳病研究现状与未来对策  

Research status and future strategies for refractory inner ear disease

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作  者:王秋菊 余力生[3] 杨仕明 WANG Qiuju;YU Lisheng;YANG Shiming(Senior Department of Otolaryngology Head and Neck Surgery,the Sixth Medical Center of Chinese PLA General Hospital,Beijing,100853,China;National Clinical Research Center for Otolaryngologic Diseases,Chinese PLA Medical School;Department of Otorhinolaryngology,Head and Neck Surgery,Peking University People's Hospital)

机构地区:[1]中国人民解放军总医院第六医学中心耳鼻咽喉头颈外科医学部,北京100853 [2]国家耳鼻咽喉疾病临床医学研究中心解放军医学院 [3]北京大学人民医院耳鼻咽喉科

出  处:《临床耳鼻咽喉头颈外科杂志》2025年第3期185-190,共6页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基  金:国家重点研发计划(No:2023YFC2508400,2023YFC2508401);国家自然科学基金项目(No:82350005)。

摘  要:难治性内耳病是指经现有的临床实践指南推荐的规范化治疗后仍不能达到良好疗效的系列内耳疾病谱。该疾病谱发病因素多样,表型异质性高,分型特征不清、致病机制不详,预后转归多样,难以精确定义。难治性内耳病在内耳病总人群中占重要比例,至今未得到系统总结、提炼和深入研究。本文首次明确提出了难治性内耳病的理念、定义和范畴,并就难治性内耳病的研究现状、面临问题和应对策略进行了阐述。相信随着科学技术的发展和进步,未来我们将见证更多新质的创新技术与新药物应用于难治性内耳病的治疗领域,为患者带来治愈的希望。Refractory inner ear disease refers to a spectrum of inner ear diseases that fail to achieve good therapeutic effects even after standardized treatment recommended by existing clinical practice guidelines.This disease spectrum is characterized by diverse etiological factors,high phenotypic heterogeneity,unclear subtype characteristics,unknown pathogenic mechanisms,and variable prognosis,making it difficult to define precisely.Refractory inner ear disease accounts for a significant proportion of the total population with inner ear diseases and has not been systematically summarized,refined,and deeply studied to date.This article,for the first time,clearly proposes the concept,definition,and scope of refractory inner ear disease,and elaborates on the current research status,challenges,and coping strategies for refractory inner ear disease.With the development and progress of science and technology,we believe that in the future we will witness more innovative technologies and new drugs applied to the treatment of refractory inner ear disease,bringing hope of cure to patients.

关 键 词:难治性内耳病 定义 精准分型 问题与挑战 对策 

分 类 号:R764.3[医药卫生—耳鼻咽喉科]

 

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