MIF与妊娠期糖尿病发病风险的相关性研究  

Correlation between MIF and risk of diabetes in pregnancy

作　　者：王艳利 王哲 张海凤 WANG Yanli;WANG Zhe;ZHANG Haifeng(Maternal and Maternal Health Department,Maternal and Child Health Hospital of Jiaozuo City,Jiaozuo,Henan 454000,China;PICU,Maternal and Child Health Hospital of Jiaozuo City,Jiaozuo,Henan 454000,China;Endocrinology Department,the First People's Hospital of Shangqiu City,Shangqiu,Henan 476000,China)

机构地区：[1]焦作市妇幼保健院孕产保健科,河南焦作454000 [2]焦作市妇幼保健院PICU,河南焦作454000 [3]商丘市第一人民医院内分泌科,河南商丘476000

出　　处：《中国医学工程》2025年第4期43-48,共6页China Medical Engineering

基　　金：河南省医学科技攻关项目(LHGJ2021002231)。

摘　　要：目的分析巨噬细胞移动抑制因子(MIF)与妊娠期糖尿病(GDM)发病风险的相关性。方法该研究为回顾性研究,将焦作市妇幼保健院2022年1月至2023年10月期间收治的62例GDM患者列为病例组,将同期接受体检的50例健康志愿者列为对照组,归纳GDM危险发病因素;验证MIF对GDM发病风险的预测效能。结果病例组中体质量指数(BMI)≥24 kg/m^(2)、合并糖尿病家族史、合并高血压、无运动习惯、内脏脂肪面积(VFA)≥10 cm^(2)、空腹血糖(FBG)≥7.0 mmol/L、餐后2 h血糖(2hPG)≥11.0 mmol/L、空腹胰岛素(FINS)>6.1 mmol/L、胰岛素抵抗指数(HOMA-IR)>2.69、MIF蛋白水平>30μg/mL、MIF mRNA相对表达量>0.5占比均高于对照组(χ^(2)=5.397、9.397、4.583、5.358、12.641、13.194、15.574、22.067、22.782、23.748、20.174,P<0.05)。BMI≥24 kg/m^(2)、VFA≥10 cm^(2)、FBG≥7.0 mmol/L、2hPG≥11.0 mmol/L、FINS>6.1 mmol/L、HOMA-IR>2.69、MIF蛋白水平>30μg/mL、MIF mRNA相对表达量>0.5为GDM发病的危险因素(P<0.05)。经检测,病例组的FBG、2hPG、FINS、HOMA-IR、MIF蛋白水平、MIF mRNA相对表达量表分别为(9.45±2.36)mmol/L、(14.49±3.23)mmol/L、(7.45±1.27)mmol/L、(3.55±0.26)、(35.25±8.42)μg/mL、(0.77±0.21),均高于对照组[(5.12±1.45)mmol/L、(9.36±1.75)mmol/L、(5.33±1.25)mmol/L、(2.12±0.31)、(28.44±5.28)μg/mL、(0.38±0.11)](t=11.355、10.094、8.844、26.550、4.981、11.877,P<0.05)。经受试者操作特征(ROC)曲线验证,MIF蛋白水平及MIF mRNA相对表达量对GDM的预测灵敏度分别为82.49%、81.72%,特异度分别为79.43%、75.36%,截断值分别为31.85μg/mL、0.58(AUC>0.85)。结论肥胖、血糖紊乱、胰岛素抵抗及MIF升高为GDM发病的危险因素,监测MIF蛋白及MIF mRNA相对表达量或可实现对GDM的早期预测。【Objective】To analyze the correlation between macrophage migration inhibitory factor(MIF)and the risk of developing gestational diabetes mellitus(GDM).【Methods】This study was a retrospective study,which included 62 GDM patients who visited Maternal and Child Health Hospital of Jiaozuo City from January 2022 to October 2023 as the case group,and 50 healthy volunteers who underwent physical examinations at the hospital during the same period as the control group.The risk factors for GDM were summarized,and the predictive efficacy of MIF on the risk of developing GDM was verified.【Results】The results of statistical univariate analysis showed that in the case group,BMI≥24 kg/m^(2),family history of diabetes,hypertension,no exercise habits,visceral fat area(VFA)≥10 cm^(2),the proportion of fasting blood glucose(FBG)≥7.0 mmol/L,2-hour postprandial blood glucose(2hPG)≥11.0 mmol/L,fasting insulin(FINS)>6.1 mmol/L,homeostatic model assessment of insulin resistance(HOMA-IR)>2.69,and MIF protein>30μg/mL,MIF mRNA>0.5 were higher than those of the control group(χ^(2)=5.397,9.397,4.583,5.358,12.641,13.194,15.574,22.067,22.782,23.748,20.174,P<0.05).The results of logistic multiple regression analysis showed that,BMI≥24 kg/m^(2),VFA≥10 cm^(2),FBG≥7.0 mmol/L,2hPG≥11.0 mmol/L,FINS>6.1 mmol/L,HOMA-IR>2.69,MIF protein>30μg/mL,MIF mRNA>0.5 were risk factors for the onset of GDM(P<0.05).After testing,the FBG,2hPG,FINS,HOMAIR,MIF protein,MIF mRNA were 9.45±2.36 mmol/L,14.49±3.23 mmol/L,7.45±1.27 mmol/L,3.55±0.26,35.25±8.42μg/mL,0.77±0.21,higher than those of the control group(5.12±1.45 mmol/L,9.36±1.75 mmol/L,5.33±1.25 mmol/L,2.12±0.31,28.44±5.28μg/mL,0.38±0.11)(t=11.355,10.094,8.844,26.550,4.981,11.877,P<0.05).Verified by reciever operating characteristic(ROC)curve,the predictive sensitivity of MIF protein level and MIF mRNA relative expression to GDM were 82.49% and 81.72%,respectively,with specificity of 79.43% and 75.36%,and cutoff values of 31.85μg/mL and 0.58(AUC>0.85).【Conclusion�

关 键 词：妊娠期糖尿病 巨噬细胞移动抑制因子 发病风险 预测效能 

分 类 号：R714.256[医药卫生—妇产科学]