中药塌渍对化疗静脉炎模型血管病理作用影响的实验研究  

Experimental study on the effect of Chinese herbal medicine soaking on vascular pathology in a chemotherapeutic phlebitis model

作　　者：黎峰[1] 占琪 吴琪 彭春燕 钟明艳 饶浔 张磊 LI Feng;ZHAN Qi;WU Qi;PENG Chun-yan;ZHONG Ming-yan;RAO Xun;ZHANG Lei

机构地区：[1]九江市妇幼保健院(九江市儿童医院、九江市妇幼保健计划生育服务中心),江西九江332000 [2]九江学院药学与生命科学学院,江西九江332000

出　　处：《中国疗养医学》2025年第5期1-5,共5页Chinese Journal of Convalescent Medicine

基　　金：江西省中医药管理局科技计划(2023B1272)。

摘　　要：目的观察中药塌渍对化疗静脉炎动物模型的疗效,分析镜下血管病理作用,探讨其防治化疗静脉炎的可能机制。方法本研究采用一次注射长春新碱法建立兔耳缘静脉炎模型,再选取兔(双侧)耳缘静脉炎模型12只,随机将每只模型左右耳分为对照组和观察组,对照组采用25%硫酸镁无菌海绵敷贴湿敷;观察组采用中药塌渍液无菌海绵敷贴湿敷。收集两组模型术后72 h静脉炎疗效评价指标,获双侧静脉标本经多聚甲醛固定和石蜡切片染色镜下观察,比较两组疗效及镜下血管病理损伤情况的统计学意义。结果观察组用药72 h后,静脉炎症状外观好于未使用中药塌渍的对照组,静脉血回流及颜色与正常静脉接近。术后72 h,观察组在0级(无症状)及1级(局部发红)的静脉条数上多于对照组。观察组在2级(局部红斑或水肿)、3级(红斑、水肿,条索状静脉形成)及4级(红斑水肿严重,条索状静脉形成>2.5 cm,有脓液渗出)的数量少于对照组。在整体上,观察组静脉炎的疗效比对照组好,差异有统计学意义(P<0.05)。术后72 h,观察组在血管内皮细胞脱落、血管周围组织水肿、炎症细胞浸润、血管内血栓形成等炎症反应的程度上,整体较对照组轻,差异均有统计学意义(均P<0.05)。观察组的炎症反应总分(3.83±4.17)分低于对照组(8.33±3.99)分,差异有统计学意义(P<0.05)。结论中药塌渍对化疗静脉炎动物模型具有显著疗效,能减轻化疗药物引起的血管病理损伤。Objective To observe the therapeutic effect of Chinese herbal medicine soaking on animal model of chemotherapeutic phlebitis,analyze the pathological effect of blood vessels under microscope,and explore the possible mechanism of prevention and treatment of chemotherapeutic phlebitis.Methods This study established a rabbit marginal auricular phlebitis model using a single injection of vincristine.Twelve rabbit(bilateral)marginal auricular phlebitis models were selected,and the left and right ears of each model were randomly divided into control group and observation group.The control group was treated with a sterile sponge dressing soaked in 25%magnesium sulfate for wet compress,while the observation group was treated with a sterile sponge dressing soaked in Chinese herbal medicine solution for wet compress.The effect evaluation indicators of phlebitis 72 hours after operation were collected from both groups.Bilateral vein specimens were fixed with paraformaldehyde and observed under a microscope after paraffin section staining.The statistical significance of the therapeutic effects and the pathological vascular damage under the microscope were compared between the two groups.Results 72 hours after treatment,the appearance of venous inflammation in the observation group was better than that in the control group without the use of Chinese herbal medicine soaking,and the venous blood reflux and color were close to normal veins.72 hours after operation,the number of veins in grade 0(asymptomatic)and grade 1(local redness)in the observation group was more than that in the control group.The number of patients in the observation group with grade 2(local erythema or edema),grade3(erythema,edema,thread-likeveinformation)andgrade4(severeerythemaedema,thread-likeveinformation>2.5cm,and pus exudation)was less than that in the control group.On the whole,the effect of phlebitis in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).72 hours after operation,th

关 键 词：中药塌渍 长春新碱 化疗 静脉炎 动物模型 血管病理作用 

分 类 号：R285.5[医药卫生—中药学]