抗感染的载药钛纳米管及其缓释的研究进展  

Research progress in anti-infection drug-loaded titanium nanotubes and their sustained release

作　　者：薛志瑞 满振涛 陈海峰[2] 李伟 XUE Zhi-rui;MAN Zhentao;CHEN Hai-feng;LI Wei(Department of Joint Surgery,Shandong Provincial Hospital,Shandong First Medical University,Jinan 250021,Shandong,China;Department of Biomedical Engineering,College of Future Technology,Peking University,Beijing 100871,China)

机构地区：[1]山东第一医科大学附属省立医院骨关节科,山东济南250021 [2]北京大学未来技术学院生物医学工程系,北京100871

出　　处：《中国矫形外科杂志》2025年第7期621-625,共5页Orthopedic Journal of China

基　　金：山东省自然科学基金面上项目(编号:ZR2022MH222);国家重点研发计划项目(编号:2023YFB4606700)。

摘　　要：钛及其合金以其优良的物理特性和生物相容性而广泛应用于骨科植入物中。由于其生物惰性,不能有效抵御感染。假体周围感染是植入物失败的主要原因之一。因此,对钛及其合金进行表面修饰成为了近年的研究热点。钛表面纳米化有利于成骨细胞的黏附,促进骨整合,二氧化钛纳米管(titanium dioxide nanotubes,TNT)不仅能够抵抗细菌的黏附,还可携带多种药物实现杀菌效果。因此,TNT成为了一种高效、理想的载药平台。同时,可对TNT进行生物学修饰实现药物的缓释,实现理想的抗菌效果。该文对钛表面纳米化载药及其缓释进行综述,为构建抗感染的骨科植入物提供新的策略。Titanium and its alloys are widely used in orthopedic implants for their excellent physical properties and biocompatibility,whereas it can not resist infection effectively due to its biological inertness.However,periprosthetic infection is one of the major causes of implant failure.and surface modification of titanium and its alloys has become a research hotspot in recent years.Titanium surface nanosizing facilitates the adhesion of osteoblasts and promotes osseointegration,and titanium dioxide nanotubes can not only resist bacterial adhesion,but also carry a variety of drugs to achieve bactericidal effect.Therefore,titanium dioxide nanotubes have become an efficient and ideal platform for drug carrying.Meanwhile,titanium dioxide nanotubes can be biologically modified to realize the sustained release of drugs and achieve the ideal antibacterial effect.This paper reviews the nanosized drug-carrying on titanium surface and its sustained release to provide a new strategy for constructing anti-infective orthopedic implants.

关 键 词：骨科植入物 二氧化钛纳米管 抗菌 载药 缓释 

分 类 号：R318[医药卫生—生物医学工程]