益赛普治疗风湿免疫疾病的临床疗效  

The clinical effect of etanercept in the treatment of rheumatic immune diseases

作　　者：陈宪 王坤坤 CHEN Xian;WANG Kun-kun(Rheumatology and Immunology Department,Tengzhou Central People's Hospital,Tengzhou Shandong Province 277599,China)

机构地区：[1]滕州市中心人民医院风湿免疫科,山东滕州277599

出　　处：《中国城乡企业卫生》2025年第3期128-130,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：目的探析风湿免疫疾病选择益赛普治疗的疗效,为风湿免疫疾病的治疗提供参考。方法选取2022年8月-2023年8月滕州市中心人民医院收治的80例风湿免疫疾病患者为观察对象,并选择随机数字表法将患者分为对照组和观察组各40例。对照组给予美洛昔康联合甲氨蝶呤治疗,观察组给予益赛普联合甲氨蝶呤治疗。比较两组患者临床疗效和不良反应发生率。结果观察组治疗总有效率为97.50%,高于对照组的85.00%,差异有统计学意义(χ^(2)=3.914,P<0.05)。观察组不良反应发生率为5.00%,低于对照组的20.00%,差异有统计学意义(χ^(2)=4.114,P<0.05)。结论在风湿免疫疾病治疗上选择益赛普效果更好,能改善患者病情,降低不良反应风险,具有较高的安全性和可耐受性,为临床医生用药选择提供有效参考和依据,对患者预后改善效果明显,值得临床推行使用。Objective To explore the effectiveness of using etanercept to treat rheumatic immune diseases,and to provide reference for the treatment of rheumatic immune diseases.Methods A total of 80 patients with rheumatic immune diseases admitted to Tengzhou Central People's Hospital from August 2022 to August 2023 were selected as the observation objects.They were divided into control group and an observation group,with 40 patients in each group,using a random number table method.The control group received meloxicam combined with methotrexate treatment,while the observation group received etanercept combined with methotrexate treatment.The treatment effectiveness and incidence of adverse reactions of the two groups of patients were compared.Results The total effective rate of treatment in the observation group was 97.50%,which was higher than 85.00%in the control group,and the difference was statistically significant(x^(2)=3.914,P<0.05).The incidence of adverse reactions in the observation group was 5.00%,which was lower than 20.00%in the control group,and the difference was statistically significant(x^(2)=4.114,P<0.05).Conclusion The effect of etanercept was more better in the treatment of rheumatic immune diseases,which could improve the patient's condition,reduce the risk of adverse reactions,it had high safety and tolerability,provided effective reference and basis for clinical doctors to choose medication,and had a significant effect on improving patient prognosis.It was worthy of clinical promotion and application.

关 键 词：风湿免疫疾病 益赛普 不良反应 效果 

分 类 号：R593[医药卫生—内科学]