氯吡格雷联合阿司匹林治疗急性心肌梗死的临床疗效分析  

Clinical effect analysis of clopidogrel combined with aspirin in the treatment of acute myocardial infarction

作　　者：徐玉亮 XU Yu-liang(Dongguo Central Health Center,Zaozhuang 277533,China)

机构地区：[1]滕州市东郭中心卫生院,277533

出　　处：《中国实用医药》2025年第7期65-68,共4页China Practical Medicine

摘　　要：目的分析对急性心肌梗死患者施以氯吡格雷、阿司匹林联合治疗的临床疗效。方法200例急性心肌梗死患者,采用抽签方法分为治疗组(100例,施以氯吡格雷、阿司匹林联合治疗)及对照组(100例,施以阿司匹林治疗)。对比两组临床疗效,血管再通及血管再闭塞情况,心功能指标[心输出量(CO)、每搏输出量(SV)、左室射血分数(LVEF)],心血管不良事件发生情况,不良反应发生情况。结果相比对照组的87.00%,治疗组总有效率98.00%明显较高(P<0.05)。相比对照组的88.00%、12.00%,治疗组血管再通率98.00%明显较高、血管再闭塞率1.00%明显较低(P<0.05)。相比对照组的(4.00±0.24)L/min、(65.13±3.16)ml、(39.53±2.53)%,治疗组治疗后CO(4.89±0.53)L/min、SV(75.47±3.42)ml、LVEF(48.58±2.12)%明显较高(P<0.05)。相比对照组的21.00%,治疗组心血管不良事件发生率6.00%明显较低(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论对急性心肌梗死患者施以氯吡格雷、阿司匹林联合治疗效果满意,有效性和安全性均较高,可使心功能得以改善,心血管不良事件降低,值得推广。Objective To analyze the clinical efficacy of clopidogrel combined with aspirin in the treatment of acute myocardial infarction.Methods A total of 200 patients with acute myocardial infarction were divided into treatment group(100 cases,clopidogrel combined with aspirin)and control group(100 cases,aspirin)by lottery method.Comparison of clinical efficacy,revascularization and vascular re-occlusion,cardiac function indicators[cardiac output(CO),stroke volume(SV),left ventricular ejection fraction(LVEF)],cardiovascular adverse events and adverse reactions between the two groups.Results Compared with 87.00%in the control group,the total effective rate in the treatment group was significantly higher at 98.00%(P<0.05).Compared with 88.00%and 12.00%in the control group,the revascularization rate in the treatment group was significantly higher at 98.00%,and the rate of vascular re-occlusion was significantly lower at 1.00%(P<0.05).Compared with(4.00±0.24)L/min,(65.13±3.16)ml and(39.53±2.53)%in the control group,CO(4.89±0.53)L/min,SV(75.47±3.42)ml and LVEF(48.58±2.12)%were significantly higher in the treatment group after treatment(P<0.05).Compared with 6.00%in the control group,the incidence of cardiovascular adverse events in the treatment group was significantly lower at 21.00%(P<0.05).There was no significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined treatment of clopidogrel and aspirin in patients with acute myocardial infarction has satisfactory effect,high efficacy and safety,which can improve cardiac function and reduce cardiovascular adverse events,and is worthy of promotion.

关 键 词：急性心肌梗死 阿司匹林 氯吡格雷 

分 类 号：R542.2[医药卫生—心血管疾病]