肺炎支原体大叶性肺炎患儿早期小剂量短疗程应用糖皮质激素的临床效果研究  

Clinical study on short-course,low-dose glucocorticosteroids in early treatment of children with Mycoplasma pneumoniae lobar pneumonia

作　　者：张明明 陈丽[2] ZHANG Ming-ming;CHEN Li(Department of Pediatrics,Zaozhuang Municipal Hospital Affiliated to Jining Medical College,Zaozhuang 277101,China)

机构地区：[1]济宁医学院附属枣庄市立医院儿科,277101 [2]济宁医学院附属枣庄市立医院耳鼻喉科,277101

出　　处：《中国实用医药》2025年第7期68-71,共4页China Practical Medicine

摘　　要：目的观察肺炎支原体大叶性肺炎患儿早期小剂量短疗程应用糖皮质激素的临床疗效及对血清炎性因子的影响。方法60例肺炎支原体大叶性肺炎患儿,按随机数字表法分为观察组(30例)及对照组(30例)。对照组给予阿奇霉素治疗,观察组在对照组治疗方案基础上给予早期小剂量短疗程注射用甲泼尼龙琥珀酸钠治疗。比较两组患儿治疗前后的白细胞介素-6(IL-6)水平,症状消失时间(热退时间、咳嗽缓解时间),肺部阴影明显吸收情况。结果治疗后,两组患儿的IL-6水平均较治疗前降低,且观察组IL-6(5.4±1.0)pg/ml显著低于对照组的(11.2±3.2)pg/ml,有统计学差异(P<0.05)。观察组患儿的热退时间(2.57±0.65)d、咳嗽缓解时间(5.27±1.85)d均短于对照组的(4.55±0.62)、(7.53±1.61)d,有统计学差异(P<0.05)。观察组患儿的肺部阴影明显吸收率80%高于对照组的50%,有统计学差异(P<0.05)。结论早期小剂量短疗程应用糖皮质激素可显著降低肺炎支原体大叶性肺炎患儿的血清炎性因子水平,有效改善临床症状,缩短病程,疗效确切。Objective To observe the clinical efficacy of short-course,low-dose glucocorticosteroids in early treatment of children with Mycoplasma pneumoniae lobar pneumonia and its influence on serum inflammatory factors.Methods 60 children with Mycoplasma pneumoniae lobar pneumonia were divided into an observation group(30 cases)and a control group(30 cases)according to random numerical table,with 30 patients in each group.The the control group was treated with azithromycin,while the observation group was treated with early treatment of short-course,low-dose Methylprednisolone sodium succinate for injection(trade name:Sou-Medrol).The levels of interleukin-6(IL-6)before and after treatment,disappearance time of symptoms(fever,cough)and the obvious absorption of lung shadow were compared between the two groups.Results After treatment,IL-6 levels in both groups were lower than those before treatment,and the observation group had a significantly lower IL-6 of(5.4±1.0)pg/ml than(11.2±3.2)pg/ml in the control group.There was statistical difference(P<0.05).The fever reduction time and cough relief time were(2.57±0.65)and(5.27±1.85)d in the observation group,which were shorter than(4.55±0.62)and(7.53±1.61)d in the control group,and there was statistical difference(P<0.05).The obvious absorption rate of lung shadow in the observation group was 80%,which was higher than 50%in the control group,and there was statistical difference(P<0.05).Conclusion Early application of short-course,low-dose glucocorticosteroids shows definite efficacy on children with Mycoplasma pneumoniae lobar pneumonia,which can significantly reduce the level of serum inflammatory factors in children,effectively improve clinical symptoms,and shorten the course of disease.

关 键 词：注射用甲泼尼龙琥珀酸钠 肺炎支原体 大叶性肺炎 炎性因子 

分 类 号：R725.6[医药卫生—儿科]