苏州队列人群健康生活方式与慢性阻塞性肺疾病发病风险的前瞻性关联研究  

Prospective association study between healthy lifestyle and the risk of developing chronic obstructive pulmonary disease in Suzhou cohort

作　　者：华钰洁 戴嘉琪 范习康 苏健[2,3] 俞浩[3] 金建荣[4] 孙点剑一[5,6,7] 裴培 陶然 周金意 陆艳[1,2] HUA Yujie;DAI Jiaqi;FAN Xikang;SU Jian;YU Hao;JIN Jianrong;SUN Dianjianyi;PEI Pei;TAO Ran;ZHOU Jinyi;LU Yan(Institute of Chronic Non-communicable Disease Prevention and Control,Suzhou Centre for Disease Control and Prevention,Suzhou,Jiangsu Province 215003,China;不详)

机构地区：[1]苏州市疾病预防控制中心慢性非传染性疾病防制所,江苏省苏州215003 [2]南京医科大学公共卫生学院,江苏省南京211166 [3]江苏省疾病预防控制中心慢性非传染性疾病防制所 [4]苏州市吴中区疾病预防控制中心 [5]北京大学公共卫生学院流行病与卫生统计学系 [6]北京大学公众健康与重大疫情防控战略研究中心 [7]重大疾病流行病学教育部重点实验室(北京大学)

出　　处：《中国慢性病预防与控制》2025年第2期81-86,共6页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：国家自然科学基金(82192900,82192901,82192904,81390540,91846303);国家重点研发计划精准医学研究重点专项(2016YFC0900500);香港Kadoorie Charitable基金;英国Wellcome Trust(202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z);江苏省科技厅社会发展重点项目(BE2019674);苏州市姑苏卫生人才计划培养项目(GSWS2020098);江苏省老年健康科研项目(LKM2023038);苏州市全国青年导师制项目(Qngg2022032);苏州科技局“科教兴卫”项目(KJXW2018051);重大疾病流行病学教育部重点实验室(北京大学)开放基金项目(2024208)。

摘　　要：目的探索健康生活方式对慢性阻塞性肺疾病(COPD)发病风险的影响,为COPD预防与干预政策的制定提供科学依据。方法基于2004—2008年中国慢性病前瞻性研究苏州市吴中区项目点数据,选取其中符合标准的45484人为研究对象,收集信息包括社会人口学特征、个人或家庭健康状况、室内空气污染情况和生活方式,其中生活方式包括吸烟、饮酒、体力活动、饮食和体型。随访人年数从基线调查开始计算,直至随访出现COPD的发病、死亡或失访,或者至2017年12月31日为止。使用R 4.3.2软件进行χ^(2)检验,采用Cox比例风险回归模型分析生活方式与COPD发病风险的关联强度。结果截至2017年12月31日,研究对象中位随访时间为11.12年,随访期间共诊断COPD 524人,COPD的发病密度为105.54/10万人年。多因素Cox比例风险回归分析显示,采用多种健康生活方式与COPD的发病风险降低相关,趋势性检验差异有统计学意义(P<0.01);单项健康生活方式中,不吸烟(HR=0.62,95%CI:0.46~0.84)、高水平体力活动(HR=0.70,95%CI:0.56~0.87)、均衡膳食(HR=0.61,95%CI:0.42~0.88)与COPD的发病风险降低呈正相关(P<0.05)。健康生活方式评分越高,COPD的发病风险越低(HR=0.82,95%CI:0.73~0.92),与至多具备1种健康生活方式相比,具备至少4种健康生活方式的研究对象,COPD发病风险降低了43%(HR=0.57,95%CI:0.40~0.83)。结论健康生活方式与较低的COPD发病风险有关,遵循健康的生活方式可以降低成年人COPD发病风险。Objective To explore the impact of healthy lifestyle on the risk of developing chronic obstructive pulmonary disease(COPD),and provide a scientific basis for the prevetion and intervention policies for COPD.Methods The data were obtained from the baseline and follow-up information of 45484 respondents aged 30-79 years old from the China Kadoorie Biobank project in Wuzhong District,Suzhou,from 2004 to 2008.Information collected included socio-demographic characteristics,personal or family health status,indoor air pollution status,and lifestyle.Lifestyle included smoking,alcohol consumption,physical activity,diet,and body mass index.Person-years followed up were calculated from the baseline survey until COPD onset,death,loss to follow-up at follow-up or until December 31,2017.The χ^(2) test was used to analyze the data.The association between lifestyle and the risk of COPD was analyzed using the Cox proportional risk regression model by R 4.3.2 software.Results As of December 31,2017,the median follow-up time of the study population was 11.12 years,and 524 people were diagnosed with COPD during the follow-up period,with an incidence density of COPD of 105.54/100000 person-years.Multifactorial Cox proportional risk regression analysis showed that the adoption of multiple healthy lifestyles was associated with a reduced risk of developing COPD,and the difference was statistically significant in the test for trend(P<0.01);among the separate healthy lifestyles,nonsmoking(HR=0.62,95%CI:0.46-0.84),high level physical activive(HR=0.70,95%CI:0.56-0.87),and healthy dietary habits(HR=0.61,95%CI:0.42-0.88)were associated with a reduced risk of developing COPD(P<0.05).Higher healthy lifestyle scores were associated with a lower risk of COPD(HR=0.82,95%CI:0.73-0.92),and study participants with at least 4 healthy lifestyles had a 43%lower risk of developing COPD compared with those with at most 1 healthy lifestyle(HR=0.57,95%CI:0.40-0.83).Conclusion Healthy lifestyle is associated with lower risk of developing COPD,and followin

关 键 词：生活方式 慢性阻塞性肺疾病 发病风险 

分 类 号：R563.9[医药卫生—呼吸系统]