肾移植患者多重耐药菌合并阿萨西毛孢子菌感染治疗一例  

Individualized treatment of multi-drug resistant bacteria and Trichosporon asasii infection in an immunocompromised patient:a case report

作　　者：李洁[1] 祝德秋[1] LI Jie;ZHU Deqiu(Department of Pharmacy,Tongji Hospital Affiliated to Tongji University,Shanghai 200065,China)

机构地区：[1]同济大学附属同济医院药剂科,上海200065

出　　处：《临床药物治疗杂志》2025年第3期90-92,共3页Clinical Medication Journal

摘　　要：本文报道1例长期服用泼尼松、吗替麦考酚酯、环孢素三联免疫抑制剂抗排异治疗的肾移植患者,行糖尿病足截肢术后,继发耐碳青霉烯的鲍曼不动杆菌感染以及阿萨西毛孢子菌感染,在临床药师参与下使用了多种抗感染药物(美罗培南、利奈唑胺、替加环素、多黏菌素E、头孢哌酮钠舒巴坦钠和伏立康唑),根据病情变化调整免疫抑制剂,感染得到有效控制。This article reports a renal transplant patient who was treated with triple immunosuppressive therapy of prednisone,mycophenolate mofetil,and cyclosporine for a long time.After diabetic foot amputation,she had secondary carbapenem-resistant Acinetobacter baumannii infection and Trichioron asaii infection,and various anti-infective agents were administered based on the patient's clinical condition.These include meropenem,linezolid,tigecycline,polymyxin E,cefoperazone sulbactam,and voriconazole.During the treatment,immunosuppressive therapy was adjusted timely,and the blood concentration monitoring results of voriconazole and cyclosporine were provided by clinical pharmacists.An optimized individualized drug administration strategy was formulated,which successfully prevented post-transplant rejection and effectively controlled the infection.

关 键 词：免疫抑制 多重耐药革兰阴性菌 阿萨西毛孢子菌 血药浓度监测 

分 类 号：R978.5[医药卫生—药品] R969.3[医药卫生—药学]