基于指纹图谱和网络药理学的人参玫瑰饮质量标志物预测分析  

Predictive analysis of quality markers of ginseng rose drink based on fingerprinting and network pharmacology

作　　者：胡娟娟 汪芮羽 韩跃威 李平 陈国瑞 石爱文 齐冬雪 齐滨[1] 刘莉[1] HU Juanjuan;WANG Ruiyu;HAN Yuewei;LI Ping;CHEN Guorui;SHI Aiwen;QI Dongxue;QI Bin;LIU Li(School of Pharmacy,Changchun University of Chinese Medicine,Changchun 130117,China;Changchun Saisi Medical Bioengineering Co.,Ltd,Changchun 130015,China)

机构地区：[1]长春中医药大学药学院,长春130117 [2]长春赛斯医疗生物工程有限公司,长春130015

出　　处：《药学前沿》2025年第4期551-559,共9页China Pharmacist

基　　金：吉林省教育厅科学技术研究项目(JJKH20230991KJ);吉林省科技发展计划项目(YDZJ202301ZYTS460);吉林省大学生创新创业训练计划项目(S202310199039)。

摘　　要：目的基于指纹图谱和网络药理学,预测人参玫瑰饮潜在的质量标志物成分。方法运用HPLC法建立10批人参玫瑰饮指纹图谱,指认并归属共有峰,进行相似度评价,以考察不同批次样品间差别;基于化学成分有效性、可测性和网络药理学对其潜在的质量标志物进行预测分析。结果指纹图谱共指认22个共有峰,其中确认8个共有峰,包括芦丁、金丝桃苷、山奈酚、尿苷、腺苷、尿囊素、人参皂苷Rg1、人参皂苷Rg3,其相似度均大于0.90;通过网络药理学预测可知,8种成分能通过多个靶点调控癌症、炎症等多条通路。结论预测芦丁、金丝桃苷、山奈酚等8种成分为人参玫瑰饮的潜在质量标志物,以期为人参玫瑰饮的质量控制及后续研究提供参考。Objective To predict the potential quality marker components of ginseng rose drink based on fingerprint and network pharmacology.Methods The fingerprints of 10 batches of ginseng rose drink were established by HPLC,the common peaks were identified and attributed to each batch of ginseng rose drink,and the similarity evaluation was conducted to examine the differences among samples from different batches.The potential quality biomarkers were predicted and analyzed based on the effectiveness,measurability of chemical composition and network pharmacology.Results A total of 22 shared peaks were identified by fingerprints,and 8 common peaks were designated,including rutin,chrysin,kaempferol,uridine,adenosine,allantoin,ginsenoside Rg1 and ginsenoside Rg3,and their similarities were all greater than 0.90.According to network pharmacology predictions,8 components could regulate multiple pathways such as cancer,inflammation,etc.Conclusion 8 components including rutin,hyperoside,kaempferol,etc,have been predicted as potential quality markers for ginseng rose drink,with a view to providing references for the quality control of ginseng rose drink and subsequent studies.

关 键 词：人参玫瑰饮 指纹图谱 网络药理学 质量标志物 高效液相色谱法 

分 类 号：R285.5[医药卫生—中药学]