糠酸莫米松喷鼻剂联合穴位敷贴及耳穴压豆治疗变应性鼻炎的疗效分析  

Efficacy of mometasone furoate nasal spray combined with acupoint application and auricular acupoint pressing bean treatment in patients with allergic rhinitis

作　　者：顾明优 史琳琳 王萍萍 邬振华[4] GU Mingyou;SHI Linlin;WANG Pingping;WU Zhenhua(Department of Otolaryngology,The Third People's Hospital of Beilun District,Ningbo City(Ningbo Li Huili Hospital,Beilun Branch),Ningbo 315801,Zhejiang Province,China;Department of Laboratory Medicine,The Third People's Hospital of Beilun District,Ningbo City(Ningbo Li Huili Hospital,Beilun Branch),Ningbo 315801,Zhejiang Province,China;Traditional Chinese Medicine Appropriate Technology Room,The Third People's Hospital of Beilun District,Ningbo City(Ningbo Li Huili Hospital,Beilun Branch),Ningbo 315801,Zhejiang Province,China;ENT&HN Surgery Department,Li Huili Hospital,Ningbo Medical Center,Ningbo 315000,Zhejiang Province,China)

机构地区：[1]宁波市北仑区第三人民医院(宁波李惠利北仑分院)耳鼻咽喉科,浙江宁波315801 [2]宁波市北仑区第三人民医院(宁波李惠利北仑分院)检验科,浙江宁波315801 [3]宁波市北仑区第三人民医院(宁波李惠利北仑分院)中医适宜技术室,浙江宁波315801 [4]宁波市医疗中心李惠利医院耳鼻咽喉头颈外科,浙江宁波315000

出　　处：《药学前沿》2025年第4期624-633,共10页China Pharmacist

基　　金：宁波市医学科技计划项目(2021Y45)。

摘　　要：目的探讨糠酸莫米松喷鼻剂联合穴位敷贴及耳穴压豆治疗变应性鼻炎(AR)患者的疗效和机制。方法回顾性收集2023年1月至10月宁波市北仑区第三人民医院诊治的AR患者的临床资料。根据诊疗方案不同分为常规治疗组(糠酸莫米松喷鼻剂)和联合治疗组(糠酸莫米松喷鼻剂联合穴位敷贴及耳穴压豆)。比较两组临床症状总分、治疗有效率、鼻结膜炎生活质量评分(RQLQ)、T淋巴细胞亚群(CD3^(+)、CD4^(+)和CD8^(+))、总免疫球蛋白E(tIgE)、白细胞介素-6(IL-6)和全血嗜酸性粒细胞计数(EOS)、鼻黏膜EOS。结果共纳入100例患者,联合治疗组49例,常规治疗组51例。与治疗前相比,治疗后两组AR患者临床症状总分和RQLQ评分均显著下降(P<0.05),且联合治疗组临床症状总分和RQLQ评分显著低于常规治疗组(P<0.05),联合治疗组治疗有效率显著高于常规治疗组(91.84%vs.74.51%,P<0.05)。在炎症免疫调节方面,与治疗前相比,治疗后两组AR患者CD3^(+)和CD4^(+)水平显著上升(P<0.05),且联合治疗组CD3^(+)和CD4^(+)水平显著高于常规治疗组(P<0.05);CD8^(+)、tIgE、IL-6、全血EOS和鼻黏膜EOS水平显著下降(P<0.05),且联合治疗组CD8^(+)、tIgE、IL-6、全血EOS和鼻黏膜EOS水平显著低于常规治疗组(P<0.05)。两组不良反应总发生率差异无统计学差异(P>0.05)。结论糠酸莫米松喷鼻剂联合穴位敷贴及耳穴压豆治疗AR疗效优于糠酸莫米松喷鼻剂,可显著改善AR患者临床症状与生活质量,其可能机制是抑制B淋巴细胞活性及炎症反应,进而抑制IgE介导的I型超敏反应。Objective To explore the efficacy and mechanism of mometasone furoate nasal spray combined with acupoint application and auricular acupoint pressing beans in the treatment of patients with allergic rhinitis(AR).Methods The clinical data of AR patients treated in The Third People's Hospital of Beilun District,Ningbo City from January 2023 to October 2023 were retrospectively collected.According to different diagnosis and treatment schemes,the patients were divided into the conventional treatment group(mometasone furoate nasal spray)and the combined treatment group(mometasone furoate nasal spray combined with acupoint application and auricular acupoint pressing beans).The total score of clinical symptoms,effective rate,rhinoconjunctivitis quality of life score(RQLQ),T lymphocyte subsets(CD3^(+),CD4^(+)and CD8^(+)),total immunoglobulin E(tIgE),interleukin-6(IL-6),whole blood eosinophil count(EOS),and nasal mucosal EOS were compared between the two groups.Results A total of 100 patients were included,with 49 in the combined treatment group and 51 in the conventional treatment group.Compared with before treatment,the total clinical symptom scores and RQLQ scores of AR patients in both groups decreased significantly after treatment(P<0.05),and the total clinical symptom scores and RQLQ scores of the combined treatment group were significantly lower than those in the conventional treatment group(P<0.05).The effective rate of the combined treatment group was significantly higher than that of the conventional treatment group(91.84%vs.74.51%,P<0.05).In terms of inflammatory immune regulation,compared with before treatment,the levels of CD3^(+)and CD4^(+)of AR patients in both groups increased significantly after treatment(P<0.05),and the levels of CD3^(+)and CD4^(+)in the combined treatment group were significantly higher than those in the conventional treatment group(P<0.05);the levels of CD8^(+),tIgE,IL-6,whole blood EOS and nasal mucosal EOS decreased significantly(P<0.05),and the levels of CD8^(+),tIgE,IL-6,whole blood

关 键 词：糠酸莫米松喷鼻剂 穴位敷贴 耳穴压豆 变应性鼻炎 

分 类 号：R969[医药卫生—药理学]