血小板来源外泌体作为药物递送载体的研究进展  

Research progress of platelet-derived exosomes as drug delivery vehicles

作　　者：龙泽纯 刘阳 谢向阳 刘辉 LONG Zechun;LIU Yang;XIE Xiangyang;LIU Hui(School of Pharmaceutical Sciences,Hubei University of Medicine,Shiyan 442000,Hubei Province,China;School of Medicine,Wuhan University of Science and Technology,Wuhan 430065,China;Medical support center,General Hospital of Central Theater Command of PLA,Wuhan 430070,China)

机构地区：[1]湖北医药学院药学院,湖北十堰442000 [2]武汉科技大学医学院,武汉430065 [3]中部战区总医院医疗保障中心,武汉430070

出　　处：《药学前沿》2025年第4期713-720,共8页China Pharmacist

基　　金：湖北省“楚天英才计划”项目[鄂卫发(2024)1号]。

摘　　要：血小板来源的外泌体(PEV)是血小板释放的纳米级细胞外囊泡亚群。研究表明,PEV在炎症反应、血管生成和癌症进展等多种生理及病理过程中发挥着重要的调控作用。得益于其纳米级尺寸特性,PEV具有显著的高渗透长滞留效应,能够有效穿透血管屏障并在疾病靶部位特异性聚集,这一特性使其成为极具潜力的药物靶向递送载体。然而,目前PEV的安全性评价体系尚未完善,其生产工艺和质量控制标准仍难以满足药品监管要求。如何在大规模生产时保障PEV的质量均一性和稳定性是下一步研发需要克服的重点。本文系统综述了PEV的生物学功能、载药制备方法及其在靶向给药领域的最新研究进展,以期为新型纳米药物载体的开发提供理论依据和实践参考。Platelet-derived exosomes(PEVs)are a subpopulation of nanoscale extracellular vesicles released by platelets.Studies have shown that PEVs play an important regulatory role in a variety of physiological and pathological processes,such as inflammatory response,angiogenesis,and cancer progression.Thanks to its nanoscale size characteristics,PEVs have a significant high permeability and long retention effect,can effectively penetrate the vascular barrier and specifically aggregate at the target site of the disease,which makes it a highly potential drug targeted delivery carrier.However,the current safety evaluation system of PEVs has not been perfected,and its production process and quality control standards are still difficult to meet drug regulatory requirements.How to ensure the quality uniformity and stability of PEVs during large-scale production is the focus of the next step of research and development.This article systematically reviews the biological functions of PEVs,drug loading preparation methods,and the latest research progress in the field of targeted drug delivery,in order to provide a theoretical basis and practical reference for the development of new nano drug carriers.

关 键 词：血小板源性外泌体 外泌体 药物递送系统 药物靶向性 

分 类 号：R951[医药卫生—药学]