S100A8/A9在炎症中的作用及机制  

The role and mechanism of S100A8/A9 in inflammation

作　　者：马紫微 曾璐 何旻蕙 邹先琼 MA Ziwei;ZENG Lu;HE Minhui;ZOU Xianqiong(Science Experiment Center,Guilin Medical University,Guilin,Guangxi 541199,China;College of Basic Medical Sciences,Guilin Medical University,Guilin,Guangxi 541199,China)

机构地区：[1]桂林医学院科学实验中心,广西桂林541199 [2]桂林医学院基础医学院,广西桂林541199

出　　处：《现代医药卫生》2025年第4期984-988,共5页Journal of Modern Medicine & Health

基　　金：国家自然科学基金项目(82160185);广西自然科学基金项目(2020GXNSFDA238026)。

摘　　要：S100A8和S100A9属于S100钙结合蛋白家族,其主要在粒细胞和单核细胞中表达。近年来,研究发现S100A8/A9在炎症过程中发挥关键作用。S100A8/A9已被证实在感染性炎症、代谢性炎症、免疫性疾病及退行性疾病等多种炎症相关疾病中发挥着重要作用。因此,深入研究S100A8/A9在炎症性疾病中的作用及机制对于揭示疾病的发生发展过程、开发新的诊断工具和治疗策略具有重大意义。该文综述了S100A8/A9在炎症相关疾病中的作用及机制,旨在为这些疾病的诊断、治疗和预防提供新的视角和思路。S100A8 and S100A9 belong to the S100 family of calcium-binding protein,which are primarily expressed in granulocytes and monocytes.In recent years,studies have found that S100A8/A9 plays a key role in the inflammatory process.S100A8/A9 has been proven to play an important role in various inflammatory-related diseases,including infectious inflammation,metabolic inflammation,immune diseases,and degenerative diseases.Therefore,in-depth research on the role and mechanisms of S100A8/A9 in inflammatory diseases is of great significance for revealing the occurrence and development process of diseases,developing new diagnostic tools,and therapeutic strategies.This article reviewed the role and mechanisms of S100A8/A9 in inflammatory-related diseases,aiming to provide new perspectives and ideas for the diagnosis,treatment,and prevention of these diseases.

关 键 词：S100A8/A9 钙卫蛋白 炎症 作用机制 综述 

分 类 号：R392[医药卫生—免疫学]