microRNAs在头颈部鳞状细胞癌中的研究进展  

Research progress of microRNAs in head and neck squamous cell carcinoma

作　　者：帕尔各娜·甫拉提 阿力比亚提·艾尼[2] Parghine·Polat;Halbiyat·Ani(The Third Clinical Medical College,Xinjiang Medical University,Urumqi,Xinjiang 830000,China;Department of Head and Neck Surgery,Affiliated Cancer Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830000,China)

机构地区：[1]新疆医科大学第三临床医学院,新疆乌鲁木齐830000 [2]新疆医科大学附属肿瘤医院头颈外科,新疆乌鲁木齐830000

出　　处：《现代医药卫生》2025年第4期1015-1018,共4页Journal of Modern Medicine & Health

基　　金：新疆医科大学医学科学研究所开放课题(YXYJ20230205)。

摘　　要：头颈部肿瘤是全球第6大最常见恶性肿瘤。头颈部鳞状细胞癌发病部位相对隐匿,早期缺乏特异性症状,较多患者发现就诊时已为局部晚期。目前,虽然针对头颈部鳞癌的综合治疗方法已经取得了一定的效果,但对于晚期患者而言,其5年生存率依然未能超过50%。因此,临床疗效的提高仍然面临诸多挑战,靶向治疗的发现为头颈部鳞癌的治疗提供了新方法。研究发现,microRNA可能对头颈部鳞癌的增殖、侵袭及转移产生影响。因此,作者进一步探索microRNA在头颈部鳞癌中的作用,为头颈部鳞癌找寻新的早期诊断标志物提供新的思路。Head and neck tumors are the sixth most common malignancies worldwide.The onset site of head and neck squamous cell carcinoma is relatively hidden,and there is no specific symptoms in the early stage.At present,although the comprehensive treatment method for head and neck squamous cell carcinoma has achieved a certain effect,for advanced patients,the five-year survival rate is still not more than 50%.Therefore,the improvement of clinical efficacy still faces many challenges.The discovery of targeted therapy provides a new method for the treatment of head and neck squamous cell carcinoma.It is found that microRNAs are implicated in modulating head and neck squamous cell carcinomamalignant behavior including proliferation,infiltration,and spread.Therefore,we further explored the role of microRNAs in head and neck squamous cell carcinoma,providing new ideas for finding new early diagnostic markers for head and neck squamous cell carcinoma.

关 键 词：微小RNA 头颈部鳞状细胞癌 靶向治疗 综述 

分 类 号：R323.1[医药卫生—人体解剖和组织胚胎学]