室管膜下区受累胶质母细胞瘤临床及影像研究进展  

Research progress in clinical and imaging studies of glioblastoma with subventricular zone involvement

作　　者：潘世娇 徐胜生[1] PAN Shijiao;XU Shengsheng(Department of Radiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院放射科,重庆400016

出　　处：《现代医药卫生》2025年第4期1019-1022,1027,共5页Journal of Modern Medicine & Health

摘　　要：胶质母细胞瘤(GBM)是成人中枢神经系统最常见和最具侵袭性的原发性肿瘤。室管膜下区(SVZ)是脑内神经干细胞富集区,是脑肿瘤的潜在来源。大量基础及临床研究表明,SVZ受累是GBM的不良预后因素,表现出独特的影像学特征及复发模式。对GBM患者深入研究可能提高术前精确诊断和预后评估,并有助于医生制定个体化治疗方案,提高患者的生存质量。该文从SVZ与肿瘤的关系、SVZ受累GBM影像学特征、分子生物学特征及治疗预后等方面进行综述。Glioblastoma(GBM)is the most common and aggressive primary tumor of the adult central nervous system.The subventricular zone(SVZ)is a rich area of neural stem cells in the brain and has been considered as a potential source of brain tumors.A large number of basic and clinical studies have shown that SVZ involvement is a poor prognostic factor for GBM,showing unique imaging features and recurrence patterns.In-depth study of GBM patients may improve preoperative accurate diagnosis and prognosis assessment,and help doctors develop individualized treatment plans to improve patients′quality of life.In this review,the relationship between SVZ and tumor,imaging features,molecular biological features and treatment prognosis of SVZ-affected GBM were reviewed.

关 键 词：胶质母细胞瘤 室管膜下区 影像学特征 分子生物学特征 综述 

分 类 号：R445[医药卫生—影像医学与核医学]