Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions  

作　　者：Naveen Jeyaraman Madhan Jeyaraman Priya Dhanpal Swaminathan Ramasubramanian Arulkumar Nallakumarasamy Sathish Muthu Gabriel Silva Santos Lucas Furtado da Fonseca JoséFábio Lana 

机构地区：[1]Department of Orthopaedics,ACS Medical College and Hospital,Dr MGR Educational and Research Institute,Chennai 600077,Tamil Nadu,India [2]Department of Orthopaedics,Orthopaedic Research Group,Coimbatore 641045,Tamil Nadu,India [3]Department of Orthopaedics,Brazilian Institute of Regenerative Medicine,Indaiatuba 13334-170,São Paulo,Brazil [4]Department of Orthopaedics,Government Medical College,Omandurar Government Estate,Chennai 600002,Tamil Nadu,India [5]Department of Orthopaedics,Jawaharlal Institute of Postgraduate Medical Education and Research–Karaikal,Puducherry 609602,India [6]Central Research Laboratory,Meenakshi Medical College Hospital and Research Institute,Meenakshi Academy of Higher Education and Research,Chennai 631552,Tamil Nadu,India

出　　处：《World Journal of Experimental Medicine》2025年第2期40-50,共11页世界实验医学杂志(英文)

摘　　要：The gut microbiome,a complex ecosystem of microorganisms,has a significant role in modulating pain,particularly within orthopaedic conditions.Its impact on immune and neurological functions is underscored by the gut-brain axis,which influences inflammation,pain perception,and systemic immune responses.This integrative review examines current research on how gut dysbiosis is associated with various pain pathways,notably nociceptive and neuroinflammatory mechanisms linked to central sensitization.We highlight advancements in meta-omics technologies,such as metagenomics and metaproteomics,which deepen our understanding of microbiome-host interactions and their implications in pain.Recent studies emphasize that gut-derived short-chain fatty acids and microbial metabolites play roles in modulating neuroinflammation and nociception,contributing to pain management.Probiotics,prebiotics,synbiotics,and faecal microbiome transplants are explored as potential therapeutic strategies to alleviate pain through gut microbiome modulation,offering an adjunct or alternative to opioids.However,variability in individual microbiomes poses challenges to standardizing these treatments,necessitating further rigorous clinical trials.A multidisciplinary approach combining microbiology,immunology,neurology,and orthopaedics is essential to develop innovative,personalized pain management strategies rooted in gut health,with potential to transform orthopaedic pain care.

关 键 词：Gut microbiome Pain management ORTHOPAEDICS Gut-brain axis PROBIOTICS Inflammation 

分 类 号：R68[医药卫生—骨科学]