Immunomodulatory effect of allium sativum in type 2 diabetes mellitus  

作　　者：Elva Manuela Mejía Delgado Juan Eduardo Quiroz-Aldave María del Carmen Durand-Vásquez Lea NoemíAldave-Pita Jenyfer María Fuentes-Mendoza Luis Alberto Concepción-Urteaga JoséPaz-Ibarra Marcio JoséConcepción-Zavaleta 

机构地区：[1]Basic Sciences of Microbiology and Immunology,School of Medicine,Universidad Nacional de Trujillo,Trujillo 13011,La Libertad,Peru [2]Non-Communicable Diseases,Endocrinology Research Line,Hospital de Apoyo Chepén,Chepén 13871,La Libertad,Peru [3]Family Medicine,Centro de Salud Mental Comunitario“Abraza la Vida”,Pueblo Nuevo 13851,La Libertad,Peru [4]School of Pharmacy and Biochemistry,Universidad Nacional de Trujillo,Trujillo 13011,La Libertad,Peru [5]Carrera de Medicina Humana,Universidad Científica del Sur,Lima 15067,Peru [6]Internal Medicine,Hospital Regional Docente de Trujillo,Trujillo 13011,La Libertad,Peru [7]School of Medicine,Universidad Nacional Mayor de San Marcos,Lima 15081,Peru [8]Department of Endocrinology,Hospital Nacional Edgardo Rebagliati Martins,Lima 15072,Peru

出　　处：《World Journal of Experimental Medicine》2025年第2期51-62,共12页世界实验医学杂志(英文)

摘　　要：Type 2 diabetes mellitus(T2DM)is a metabolic disorder marked by chronic hyperglycemia and low-grade inflammation,contributing to various complications.Natural agents with immunomodulatory and antioxidant properties have gained attention as adjunct therapies.To review the effects of Allium sativum on inflammatory pathways and metabolic alterations associated with T2DM.A narrative review was performed using PubMed/MEDLINE,EMBASE,and Scielo databases.The search included terms such as“allium sativum”,“inflammation",“oxidative stress”,and“diabetes mellitus”.Studies in English and Spanish-ranging from clinical trials to meta-analyses-were selected based on relevance.Bioactive compounds such as allicin,S-allyl cysteine,and diallyl disulfide exhibit anti-inflammatory,antioxidant,hypoglycemic,and lipid-lowering actions.Preclinical studies show improved glucose metabolism,insulin sensitivity,and organ function.Moreover,clinical evidence supports reductions in fasting glucose,hemoglobin A1c,blood pressure,and oxidative stress,with good safety profiles.Allium sativum appears to be a promising adjuvant in T2DM management,offering metabolic and anti-inflammatory benefits.Nonetheless,further high-quality clinical trials are needed to confirm its long-term efficacy and standardize its therapeutic use.

关 键 词：GARLIC PHYTOTHERAPY Anti-inflammatory agents ANTIOXIDANTS Immunomodulating agents Type 2 diabetes mellitus 

分 类 号：R587.1[医药卫生—内分泌]